Nothjunge J
Abteilung Allgemeine Pädiatrie der Universitäts-Kinderklinik Tübingen.
Dtsch Med Wochenschr. 1989 Dec 22;114(51-52):1996-2000. doi: 10.1055/s-2008-1066860.
Sixty-four children with type 1 diabetes (33 girls and 31 boys with a mean age of 11 1/4 years) were studied in order to ascertain whether urine sugar measurements performed by the patients or their parents can provide adequate monitoring of treatment. The results of two home-testing methods for urine glucose were compared with subsequent glucose dehydrogenase assays in the laboratory. Over the range from 0 to 5 g/dl the results of home testing disagreed with the laboratory checks by an average of one concentration grade, and displayed wide scatter. Only in the concentration range of 0.5 g/dl were there differences between the nonspecific reduction test (Clinitest) and the specific enzymatic assay. Glucose concentrations in urine specimens passed at 7 am, 12 noon and 6 pm (home testing) were compared with blood glucose concentrations checked at the same times. Correlation was not very close (correlation coefficients between 0.3 and 0.64). Correlation between pooled urine collections and 24 hour blood sugar profiles was equally poor (0.5-0.6). The author concludes that urine sugar testing is unsatisfactory for home monitoring of children with diabetes and the results are inadequate for diagnostic or therapeutic purposes.
为了确定由患者或其父母进行的尿糖测量是否能为治疗提供充分监测，对64名1型糖尿病儿童（33名女孩和31名男孩，平均年龄为11¼岁）进行了研究。将两种家庭尿葡萄糖检测方法的结果与随后实验室中的葡萄糖脱氢酶测定结果进行了比较。在0至5g/dl的范围内，家庭检测结果与实验室检查结果平均相差一个浓度等级，且离散度较大。仅在0.5g/dl的浓度范围内，非特异性还原试验（Clinitest）和特异性酶测定之间存在差异。比较了上午7点、中午12点和下午6点（家庭检测）采集的尿标本中的葡萄糖浓度与同一时间检测的血糖浓度。相关性不是很紧密（相关系数在0.3至0.64之间）。混合尿样本与24小时血糖谱之间的相关性同样较差（0.5 - 0.6）。作者得出结论，尿糖检测对于糖尿病儿童的家庭监测并不令人满意，其结果对于诊断或治疗目的而言是不充分的。
