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新兴科学家的新兴毒性模型。

Emerging Toxicity Models from Emerging Scientists.

作者信息

Allard Patrick

机构信息

Department of Environmental Health Sciences and Institute for Society and Genetics, University of California, Los Angeles; Los Angeles, CA.

出版信息

Toxicol Res (Camb). 2015 May 1;4(3):545-547. doi: 10.1039/C4TX00085D.

DOI:10.1039/C4TX00085D
PMID:25987979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4433035/
Abstract

Toxicology has seen a recent influx of new talents from other fields attracted by the application of their expertise to pressing questions of toxicological and environmental relevance. This transition has opened the door to innovative and exciting scientific opportunities but has also generated a new set of questions and challenges. In this viewpoint article, I will highlight some of the drivers and hurdles encountered by the recent new breeds of toxicologists.

摘要

毒理学领域最近吸引了其他领域的一批新人才,他们将自己的专业知识应用于与毒理学和环境相关的紧迫问题。这种转变为创新和令人兴奋的科学机遇打开了大门,但也带来了一系列新的问题和挑战。在这篇观点文章中,我将重点介绍近期新一代毒理学家所面临的一些驱动因素和障碍。

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本文引用的文献

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The adverse outcome pathway concept: a pragmatic tool in toxicology.不良结局途径概念:毒理学中的实用工具。
Toxicology. 2013 Oct 4;312:158-65. doi: 10.1016/j.tox.2013.08.011. Epub 2013 Aug 23.
2
A C. elegans screening platform for the rapid assessment of chemical disruption of germline function.利用秀丽隐杆线虫进行快速筛选以评估化学物质对生殖系功能的干扰。
Environ Health Perspect. 2013 Jun;121(6):717-24. doi: 10.1289/ehp.1206301. Epub 2013 Apr 19.
3
Production of hepatocyte-like cells from human pluripotent stem cells.人多能干细胞向肝样细胞的分化。
Nat Protoc. 2013 Feb;8(2):430-7. doi: 10.1038/nprot.2012.153.
4
Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease.醛脱氢酶抑制作为帕金森病的发病机制。
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):636-41. doi: 10.1073/pnas.1220399110. Epub 2012 Dec 24.
5
Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.从体外原始生殖细胞样细胞衍生的卵母细胞中获得的后代小鼠。
Science. 2012 Nov 16;338(6109):971-5. doi: 10.1126/science.1226889. Epub 2012 Oct 4.
6
Zebrafish developmental screening of the ToxCast™ Phase I chemical library.斑马鱼胚胎发育毒性筛查 ToxCastTM 一期化学文库。
Reprod Toxicol. 2012 Apr;33(2):174-87. doi: 10.1016/j.reprotox.2011.10.018. Epub 2011 Dec 9.
7
Thalidomide-induced limb defects: resolving a 50-year-old puzzle.沙利度胺导致的肢体缺陷:解开一个 50 年的谜题。
Bioessays. 2009 Dec;31(12):1327-36. doi: 10.1002/bies.200900103.
8
The ToxCast program for prioritizing toxicity testing of environmental chemicals.用于对环境化学品毒性测试进行优先级排序的ToxCast计划。
Toxicol Sci. 2007 Jan;95(1):5-12. doi: 10.1093/toxsci/kfl103. Epub 2006 Sep 8.