Mewis Ryan E, Fekete Marianna, Green Gary G R, Whitwood Adrian C, Duckett Simon B
Centre for Hyperpolarisation in Magnetic Resonance, University of York, Heslington, York YO10 5NY, UK.
Chem Commun (Camb). 2015 Jun 18;51(48):9857-9. doi: 10.1039/c5cc01896j.
The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.
用于可逆交换信号放大（SABRE）过程的催化剂在促进底物超极化的同时，会加快弛豫速率。因此，超极化造影剂可见的寿命会大幅缩短。我们表明，添加螯合配体（如联吡啶）会迅速使SABRE催化剂失活，从而延长造影剂的弛豫时间，并提高SABRE用于诊断性磁共振成像的潜力。
