Andraus Wellington, Pinheiro Rafael Soares, Lai Quirino, Haddad Luciana B P, Nacif Lucas S, D'Albuquerque Luiz Augusto C, Lerut Jan
Digestive Organs Transplant Unit, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Department of Hepatic Surgery and Liver Transplantation, Azienda Universitario-ospedaliera Pisana, Pisa, Italy.
BMC Surg. 2015 May 21;15:65. doi: 10.1186/s12893-015-0052-y.
Patients with cirrhosis have a high incidence of abdominal wall hernias and carry an elevated perioperative morbidity and mortality. The optimal surgical management strategy as well as timing of abdominal hernia repair remains controversial.
A cohort study of 67 cirrhotic patients who underwent hernia repair during the period of January 1998-December 2009 at the University Hospital of Sao Paulo were included. After meeting study criteria, a total of 56 patients who underwent 61 surgeries were included in the final analysis. Patient characteristics, morbidity (Clavien score), mortality, Child-Turcotte-Pugh score, MELD score, use of prosthetic material, and elective or emergency surgery have been analysed with regards to morbidity and 30-day mortality.
The median MELD score of the patient population was 14 (range: 6 to 24). Emergency surgery was performed in 34 patients because of ruptured hernia (n = 13), incarceration (n = 10), strangulation (n = 4), and skin necrosis or ulceration (n = 7). Elective surgery was performed in 27 cases. After a multivariable analysis, emergency surgery (OR 7.31; p 0.017) and Child-Pugh C (OR 4.54; p 0.037) were risk factors for major complications. Moreover, emergency surgery was a unique independent risk factor for 30-day mortality (OR 10.83; p 0.028).
Higher morbidity and mortality are associated with emergency surgery in advanced cirrhotic patients. Therefore, using cirrhosis as a contraindication for hernia repair in all patients may be reconsidered in the future, especially after controlling ascites and in those patients with hernias that are becoming symptomatic or show signs of possible skin necrosis and rupture. Future prospective randomized studies are needed to confirm this surgical strategy.
肝硬化患者腹壁疝发病率高,围手术期发病率和死亡率也较高。腹部疝修补的最佳手术管理策略以及手术时机仍存在争议。
纳入1998年1月至2009年12月期间在圣保罗大学医院接受疝修补术的67例肝硬化患者进行队列研究。符合研究标准后,最终分析纳入了56例接受61次手术的患者。分析了患者特征、发病率(Clavien评分)、死亡率、Child-Turcotte-Pugh评分、MELD评分、人工材料的使用以及择期或急诊手术与发病率和30天死亡率的关系。
患者人群的MELD评分中位数为14(范围:6至24)。34例患者因疝破裂(n = 13)、嵌顿(n = 10)、绞窄(n = 4)以及皮肤坏死或溃疡(n = 7)接受了急诊手术。27例患者接受了择期手术。多变量分析后,急诊手术(OR 7.31;p 0.017)和Child-Pugh C级(OR 4.54;p 0.037)是主要并发症的危险因素。此外,急诊手术是30天死亡率的唯一独立危险因素(OR 10.83;p 0.028)。
晚期肝硬化患者急诊手术的发病率和死亡率较高。因此,未来可能需要重新考虑将肝硬化作为所有患者疝修补术的禁忌证,尤其是在控制腹水后以及那些疝出现症状或有皮肤坏死和破裂迹象的患者中。需要未来的前瞻性随机研究来证实这种手术策略。