Gray Stephen H, Vick Catherine C, Graham Laura A, Finan Kelly R, Neumayer Leigh A, Hawn Mary T
Deep South Center for Effectiveness Research, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA.
J Gastrointest Surg. 2008 Apr;12(4):675-81. doi: 10.1007/s11605-008-0496-9.
This study was undertaken to examine the effect of cirrhosis on elective and emergent umbilical herniorrhapy outcomes.
Procedures were identified from the Veterans' Affairs National Surgical Quality Improvement Program at 16 hospitals. Medical records and operative reports were physician abstracted to obtain preoperative and intraoperative variables.
Of the 1,421 cases reviewed, 127 (8.9%) had cirrhosis. Cirrhotics were more likely to undergo emergent repair (26.0% vs. 4.8%, p < 0.0001), concomitant bowel resection (8.7% vs. 0.8%, p < 0.0001), return to operating room (7.9% vs. 2.5%, p = 0.0006), and increased postoperative length of stay (4.0 vs. 2.0 days, p = 0.01). Best-fit regression models found cirrhosis was not a significant predictor of postoperative complications. Significant predictors of complications were emergent case (OR 5.4; 95% CI 3.1-9.4), diabetes (OR 2.1; 95% CI 1.2-3.8), congestive heart failure (OR 4.0; 95% CI 1.4-11.4), and chronic obstructive pulmonary disease (OR 2.0; 95% CI 1.1-3.6). Among emergent repairs, cirrhosis (OR 4.4; 95% CI 1.3-14.3) was strongly associated with postoperative complications.
Elective repair in cirrhotics is associated with similar outcomes as in patients without cirrhosis. Emergent repair in cirrhotics is associated with worse outcomes. Early elective repair may improve the overall outcomes for patients with cirrhosis.
本研究旨在探讨肝硬化对择期和急诊脐疝修补术预后的影响。
从16家医院的退伍军人事务部国家外科质量改进项目中识别手术病例。医生对病历和手术报告进行摘要,以获取术前和术中变量。
在1421例回顾病例中,127例(8.9%)患有肝硬化。肝硬化患者更有可能接受急诊修补术(26.0%对4.8%,p<0.0001)、同期肠切除术(8.7%对0.8%,p<0.0001)、返回手术室(7.9%对2.5%,p = 0.0006),且术后住院时间延长(4.0天对2.0天,p = 0.01)。最佳拟合回归模型发现,肝硬化不是术后并发症的显著预测因素。并发症的显著预测因素为急诊病例(比值比5.4;95%置信区间3.1 - 9.4)、糖尿病(比值比2.1;95%置信区间1.2 - 3.8)、充血性心力衰竭(比值比4.0;95%置信区间1.4 - 11.4)和慢性阻塞性肺疾病(比值比2.0;95%置信区间1.1 - 3.6)。在急诊修补术中,肝硬化(比值比4.4;95%置信区间1.3 - 14.3)与术后并发症密切相关。
肝硬化患者的择期修补术预后与无肝硬化患者相似。肝硬化患者的急诊修补术预后较差。早期择期修补术可能改善肝硬化患者的总体预后。