用于骨关节炎检测和治疗的基于颗粒的技术。
Particle-based technologies for osteoarthritis detection and therapy.
作者信息
Kavanaugh Taylor E, Werfel Thomas A, Cho Hongsik, Hasty Karen A, Duvall Craig L
机构信息
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
University of Tennessee Health Science Center, Memphis, TN, USA.
出版信息
Drug Deliv Transl Res. 2016 Apr;6(2):132-47. doi: 10.1007/s13346-015-0234-2.
Abstract
Osteoarthritis (OA) is a disease characterized by degradation of joints with the development of painful osteophytes in the surrounding tissues. Currently, there are a limited number of treatments for this disease, and many of these only provide temporary, palliative relief. In this review, we discuss particle-based drug delivery systems that can provide targeted and sustained delivery of imaging and therapeutic agents to OA-affected sites. We focus on technologies such as polymeric micelles and nano-/microparticles, liposomes, and dendrimers for their potential treatment and/or diagnosis of OA. Several promising studies are highlighted, motivating the continued development of delivery technologies to improve treatments for OA.
摘要
骨关节炎（OA）是一种以关节退化并在周围组织中形成疼痛性骨赘为特征的疾病。目前，针对这种疾病的治疗方法有限，而且其中许多方法只能提供暂时的、缓解症状的治疗。在本综述中，我们讨论了基于颗粒的药物递送系统，该系统可以将成像剂和治疗剂靶向并持续递送至受OA影响的部位。我们重点关注聚合物胶束、纳米/微粒、脂质体和树枝状大分子等技术在OA治疗和/或诊断方面的潜力。文中突出介绍了几项有前景的研究，这促使人们继续开发递送技术以改善OA的治疗方法。
相似文献
1
Particle-based technologies for osteoarthritis detection and therapy.用于骨关节炎检测和治疗的基于颗粒的技术。
Drug Deliv Transl Res. 2016 Apr;6(2):132-47. doi: 10.1007/s13346-015-0234-2.
2
Advance of the application of nano-controlled release system in ophthalmic drug delivery.纳米控释系统在眼科药物递送中的应用进展
Drug Deliv. 2016 Oct;23(8):2897-2901. doi: 10.3109/10717544.2015.1116025. Epub 2015 Dec 3.
3
Applications of nanosystems to anticancer drug therapy (Part II. Dendrimers, micelles, lipid-based nanosystems).纳米系统在抗癌药物治疗中的应用（第二部分。树枝状大分子、胶束、基于脂质的纳米系统）。
Recent Pat Anticancer Drug Discov. 2014 Jan;9(1):99-128. doi: 10.2174/1574891x113089990038.
4
Heart targeted nanoliposomal/nanoparticles drug delivery: An updated review.靶向心脏的纳米脂质体/纳米颗粒药物递送：最新综述。
Biomed Pharmacother. 2017 Feb;86:316-323. doi: 10.1016/j.biopha.2016.12.009. Epub 2016 Dec 21.
5
Drug Delivery Systems for the Treatment of Knee Osteoarthritis: A Systematic Review of In Vivo Studies.用于治疗膝骨关节炎的药物递送系统：体内研究的系统评价。
Int J Mol Sci. 2021 Aug 24;22(17):9137. doi: 10.3390/ijms22179137.
6
Stimuli-Sensitive Nanotherapies for the Treatment of Osteoarthritis.用于治疗骨关节炎的刺激敏感型纳米疗法。
Macromol Biosci. 2021 Nov;21(11):e2100280. doi: 10.1002/mabi.202100280. Epub 2021 Aug 16.
7
Application of gold nanoparticles in biomedical and drug delivery.金纳米颗粒在生物医学与药物递送中的应用。
Artif Cells Nanomed Biotechnol. 2016;44(1):410-22. doi: 10.3109/21691401.2014.955107. Epub 2014 Sep 17.
8
Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy.纳米颗粒主要参数对其物理化学性质的影响及纳米药物递送系统在靶向化疗中的最新应用
Int J Nanomedicine. 2017 Nov 28;12:8483-8493. doi: 10.2147/IJN.S148359. eCollection 2017.
9
Nanocrystals of a potent p38 MAPK inhibitor embedded in microparticles: Therapeutic effects in inflammatory and mechanistic murine models of osteoarthritis.纳米晶强效 p38 MAPK 抑制剂嵌入微颗粒：在炎症和机械性骨关节炎的小鼠模型中的治疗效果。
J Control Release. 2018 Apr 28;276:102-112. doi: 10.1016/j.jconrel.2018.03.007. Epub 2018 Mar 7.
10
Recent advances in targeted drug delivery for treatment of osteoarthritis.靶向药物递送治疗骨关节炎的最新进展。
Curr Opin Rheumatol. 2021 Jan;33(1):94-109. doi: 10.1097/BOR.0000000000000761.
引用本文的文献
1
Molecular signaling pathways in osteoarthritis and biomaterials for cartilage regeneration: a review.骨关节炎中的分子信号通路与用于软骨再生的生物材料：综述
Bioengineered. 2025 Dec;16(1):2501880. doi: 10.1080/21655979.2025.2501880. Epub 2025 May 7.
2
A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis.一种基于基质金属蛋白酶敏感肽的多功能平台，用于关节炎的新型诊断和治疗策略。
Bioact Mater. 2025 Jan 18;47:100-120. doi: 10.1016/j.bioactmat.2025.01.011. eCollection 2025 May.
3
Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice.类视黄醇浸渍的纳米颗粒可通过对小鼠软骨内成骨的位点特异性调节来控制骨骼生长。
J Bone Miner Res. 2025 Apr 21;40(4):535-547. doi: 10.1093/jbmr/zjaf018.
4
Therapeutic Controlled Release Strategies for Human Osteoarthritis.人类骨关节炎的治疗性控释策略
Adv Healthc Mater. 2025 Jan;14(2):e2402737. doi: 10.1002/adhm.202402737. Epub 2024 Nov 6.
5
Poly(-coumaric acid) nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis.聚（香豆酸）纳米颗粒通过抑制软骨细胞铁死亡减轻颞下颌关节骨关节炎。
Bioact Mater. 2024 Jun 12;40:212-226. doi: 10.1016/j.bioactmat.2024.06.007. eCollection 2024 Oct.
6
Controlled Release of Drugs from Extracellular Matrix-Derived Peptide-Based Nanovesicles through Tailored Noncovalent Interactions.通过定制的非共价相互作用从细胞外基质衍生的肽基纳米囊泡中控制药物释放。
Biomacromolecules. 2024 Apr 8;25(4):2408-2422. doi: 10.1021/acs.biomac.3c01361. Epub 2024 Mar 28.
7
Formation of Hydrophilic Nanofibers from Nanostructural Design in the Co-Encapsulation of Celecoxib through Electrospinning.通过静电纺丝在塞来昔布共包封中利用纳米结构设计制备亲水性纳米纤维。
Pharmaceutics. 2023 Feb 22;15(3):730. doi: 10.3390/pharmaceutics15030730.
8
Cerium oxide nanoparticles protect against chondrocytes and cartilage explants from oxidative stress Nrf2/HO-1 pathway in temporomandibular joint osteoarthritis.氧化铈纳米颗粒通过Nrf2/HO-1途径保护颞下颌关节骨关节炎中的软骨细胞和软骨外植体免受氧化应激。
Front Bioeng Biotechnol. 2023 Feb 3;11:1076240. doi: 10.3389/fbioe.2023.1076240. eCollection 2023.
9
Non-invasive brain stimulation for osteoarthritis.用于骨关节炎的非侵入性脑刺激
Front Aging Neurosci. 2022 Sep 29;14:987732. doi: 10.3389/fnagi.2022.987732. eCollection 2022.
10
[Research progress of nanomaterials for intra-articular targeted drug delivery in treatment of osteoarthritis].纳米材料用于骨关节炎关节内靶向给药治疗的研究进展
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2022 Jul 15;36(7):908-914. doi: 10.7507/1002-1892.202203033.
本文引用的文献
1
Detection of early cartilage damage using targeted nanosomes in a post-traumatic osteoarthritis mouse model.在创伤后骨关节炎小鼠模型中使用靶向纳米体检测早期软骨损伤
Nanomedicine. 2015 May;11(4):939-46. doi: 10.1016/j.nano.2015.01.011. Epub 2015 Feb 11.
2
Enhanced Performance of Plasmid DNA Polyplexes Stabilized by a Combination of Core Hydrophobicity and Surface PEGylation.通过核心疏水性和表面聚乙二醇化相结合实现稳定化的质粒DNA多聚体的性能增强
J Mater Chem B. 2014 Dec 14;2(46):8154-8164. doi: 10.1039/C4TB00352G.
3
ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease.用于糖尿病外周动脉疾病模型中按需抗氧化治疗的ROS响应性微球。
Biomaterials. 2015 Feb;41:166-75. doi: 10.1016/j.biomaterials.2014.11.016. Epub 2014 Dec 9.
4
Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers.调整混合胶束的聚乙二醇化以克服细胞内和全身小干扰RNA递送障碍。
Biomaterials. 2015 Jan;38:97-107. doi: 10.1016/j.biomaterials.2014.10.036. Epub 2014 Nov 1.
5
Dual MMP7-proximity-activated and folate receptor-targeted nanoparticles for siRNA delivery.用于小干扰RNA递送的双基质金属蛋白酶7近程激活和叶酸受体靶向纳米颗粒
Biomacromolecules. 2015 Jan 12;16(1):192-201. doi: 10.1021/bm501394m. Epub 2014 Dec 19.
6
A reduction and pH dual-sensitive polymeric vector for long-circulating and tumor-targeted siRNA delivery.一种具有还原和 pH 双重敏感性的聚合物载体，用于长循环和肿瘤靶向 siRNA 递送。
Adv Mater. 2014 Dec 23;26(48):8217-24. doi: 10.1002/adma.201403877. Epub 2014 Oct 31.
7
The challenges facing block copolymer micelles for cancer therapy: In vivo barriers and clinical translation.用于癌症治疗的嵌段共聚物胶束面临的挑战：体内障碍和临床转化。
Adv Drug Deliv Rev. 2015 Aug 30;91:7-22. doi: 10.1016/j.addr.2014.10.001. Epub 2014 Oct 13.
8
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery.多功能、刺激响应型纳米颗粒给药系统。
Nat Rev Drug Discov. 2014 Nov;13(11):813-27. doi: 10.1038/nrd4333. Epub 2014 Oct 7.
9
Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis.单剂量关节内注射FX006在大鼠反复局部膝关节关节炎模型中的持续疗效。
Osteoarthritis Cartilage. 2015 Jan;23(1):151-60. doi: 10.1016/j.joca.2014.09.019. Epub 2014 Sep 26.
10
Matrix Metalloproteinase Responsive, Proximity-activated Polymeric Nanoparticles for siRNA Delivery.用于小干扰RNA递送的基质金属蛋白酶响应性、邻近激活的聚合物纳米颗粒
Adv Funct Mater. 2013 Jun 25;23(24):3040-3052. doi: 10.1002/adfm.201202215.
Zotero 插件