Alekseeva L M, Apollonova L A, Belopol'skiĭ A A, Kolesova O E, Lebkova N P
Farmakol Toksikol. 1989 Sep-Oct;52(5):87-91.
The conditions of some biochemical and functional systems of the rat organisms at daily intramuscular injections of obsidan (0.05 mg/100 g body weight) for one month were studied to evaluate the effect of obsidan on the adrenergic-dependent adaptive reactions. It was shown that the procedure of injections itself (the control group of animals receiving injections of sodium chloride isotonic solution) is stress leading to a decrease of beta-adrenergic-dependent reactions and an increase of alpha-adrenergic-dependent ones. The combination of this stress with the pharmacological effect of obsidan is characterized by a decrease of adrenaline release in blood, a reduction of manifestations of alpha-adrenergic reactions, a decline of lipid energy substrates consumption level.
为评估黑曜石对肾上腺素依赖性适应性反应的影响，研究了大鼠机体在每日肌肉注射黑曜石（0.05毫克/100克体重）持续一个月时某些生化和功能系统的状况。结果表明，注射操作本身（接受等渗氯化钠溶液注射的动物对照组）即为应激源，会导致β肾上腺素依赖性反应减少，α肾上腺素依赖性反应增加。这种应激与黑曜石的药理作用相结合的特点是血液中肾上腺素释放减少、α肾上腺素反应表现减轻、脂质能量底物消耗水平下降。
