Markel' A L, Amstislavskiĭ S Ia, Naumenko E V
Biull Eksp Biol Med. 1986 Dec;102(12):668-70.
Adrenergic mechanisms of blood pressure regulation were studied in a newly developed strain of rats with inherited stress-provoked arterial hypertension, spontaneously hypertensive rats (SHR) and normotensive Wistar rats. A number of adrenergic agonists (noradrenaline, adrenaline, phenylephrine, clonidine, naphazoline, isoproterenol, dobutamine, Alupent) were infused into the lateral brain ventricle under nembutal anesthesia and the reaction of the peripheral blood pressure was measured. It was shown that blood pressure reactions were similar in rats with inherited stress-provoked arterial hypertension and in SHR but significantly differed from those of normotensive Wistar rats. The data obtained suggest that the development of inherited hypertension was accompanied by changes in alpha 1 to alpha 2 adrenoreceptor ratio in pressor and depressor brain regions. A decrease in the depressor effect after stimulation of beta 1 and beta 2 receptors has been also observed.
在新培育出的具有遗传性应激诱发动脉高血压的大鼠品系（自发性高血压大鼠，即SHR）以及血压正常的Wistar大鼠中，对血压调节的肾上腺素能机制进行了研究。在戊巴比妥麻醉下，将多种肾上腺素能激动剂（去甲肾上腺素、肾上腺素、去氧肾上腺素、可乐定、萘甲唑啉、异丙肾上腺素、多巴酚丁胺、喘速宁）注入侧脑室，并测量外周血压的反应。结果显示，遗传性应激诱发动脉高血压大鼠和SHR的血压反应相似，但与血压正常的Wistar大鼠的反应显著不同。所获得的数据表明，遗传性高血压的发生伴随着升压和降压脑区α1与α2肾上腺素能受体比例的变化。刺激β1和β2受体后降压效应的降低也已被观察到。
