Kabanov A V, Chekhonin V P, Batrakova E V, Lebedev A S, Melik-Nubarov N S, Arzhakov S A, Levashov A V, Morozov G V, Severin E S
Research Center of Molecular Diagnostics, USSR Ministry of Health, Moscow.
FEBS Lett. 1989 Dec 4;258(2):343-5. doi: 10.1016/0014-5793(89)81689-8.
It has been suggested to use surfactant micelles as microcontainers for increasing the efficiency of neuroleptic targeting from blood flow into the brain. The neuroleptic action of haloperidol, intraperitoneally injected into mice in micellar solution of non-ionic block copolymer surfactant (pluronic P-85) in water, increased several-fold if compared with that observed for haloperidol aqueous solution. Incorporation of brain-specific antibodies into haloperidol-containing micelles resulted in additional drastic increase (more than by 2 orders of magnitude) in the drug effect.
