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神经纳米技术:应用神经科学中的诊断和治疗型纳米基策略。

Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience.

机构信息

Department of Emergency Medicine, School of Medicine, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Biomed Eng Online. 2023 Jan 2;22(1):1. doi: 10.1186/s12938-022-01062-y.

Abstract

Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have been progressively used by neuroscientists during the last several decades. The introduction of novel implantable bioelectronics interfaces that are better suited to their biological targets is one example of an innovation that has emerged as a result of advanced nanostructures and implantable bioelectronics interfaces, which has increased the potential of prostheses and neural interfaces. The unique physical-chemical properties of nanoparticles have also facilitated the development of novel imaging instruments for advanced laboratory systems, as well as intelligently manufactured scaffolds and microelectrodes and other technologies designed to increase our understanding of neural tissue processes. The incorporation of nanotechnology into physiology and cell biology enables the tailoring of molecular interactions. This involves unique interactions with neurons and glial cells in neuroscience. Technology solutions intended to effectively interact with neuronal cells, improved molecular-based diagnostic techniques, biomaterials and hybridized compounds utilized for neural regeneration, neuroprotection, and targeted delivery of medicines as well as small chemicals across the blood-brain barrier are all purposes of the present article.

摘要

在过去的几十年中,神经科学家逐渐使用了人工合成的、全新制造的材料(具有可控的纳米级特性)。由于先进的纳米结构和可植入生物电子学接口的出现,出现了一种创新,即更好地适应生物靶标的新型可植入生物电子学接口,这增加了假肢和神经接口的潜力。纳米颗粒的独特物理化学特性还促进了用于先进实验室系统的新型成像仪器的开发,以及智能制造的支架和微电极以及其他旨在增进我们对神经组织过程的理解的技术。将纳米技术纳入生理学和细胞生物学可以实现分子相互作用的定制。这涉及到神经科学中与神经元和神经胶质细胞的独特相互作用。本文旨在解决与神经元细胞有效相互作用的技术解决方案、改进的基于分子的诊断技术、用于神经再生、神经保护以及靶向药物和小分子穿过血脑屏障递送至靶向部位的生物材料和杂交化合物等问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d4f/9809121/f401285bde14/12938_2022_1062_Fig1_HTML.jpg

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