Ceusters Werner, Smith Barry
Department of Biomedical Informatics, University at Buffalo, NY, USA.
Department of Philosophy, University at Buffalo, NY, USA.
Stud Health Technol Inform. 2015;210:155-9.
A great deal of recent work has been devoted to the topic of biomarkers as aids to diagnosis, prognosis and treatment evaluation. Basing our work on the Ontology for General Medical Science (OGMS) and on the specifications provided by the Institute of Medicine (IOM), we propose definitions for biomarkers of various types. These definitions provide a formal representation of what biomarkers are in a way that allows us to remove certain ambiguities and inconsistencies in the documentation provided by the IOM.
近期大量工作致力于生物标志物这一主题,将其作为辅助诊断、预后评估及治疗评价的手段。我们以通用医学科学本体论(OGMS)以及医学研究所(IOM)提供的规范为基础开展工作,提出了各类生物标志物的定义。这些定义以一种能让我们消除IOM所提供文档中的某些模糊性和不一致性的方式,对生物标志物是什么进行了形式化表述。