[The detoxifying function of the liver following its denervation in rats].

The content of cytochrome P450 and b5 as well as basic microsomal enzymatic activity were studied in the liver of mixed male rats within 7 days of subdiaphragmatic vagotomy and/or large and small sympathetic nerves cutting. A decrease in the content of cytochromes and amidopyrine-N-demethylase, aniline-hydroxylase and MADP-H-cytochrome-c-reductase activity was discovered both in the vagotomy and in the sympathectomy. A total denervation of the liver leads to a more significant suppression of enzymatic activity. A revealed acceleration of the blood flow and an insignificant decrease of the oxygen tension in the denervated liver tissue suggest that the above changes were due to switched off regulation of the nervous system rather than to the consequence of hypoxia.