Kello D
Toxicology and Food Safety, Environment and Health Service, World Health Organization, Copenhagen, Denmark.
Food Addit Contam. 1989;6 Suppl 1:S79-85. doi: 10.1080/02652038909373761.
Following the successful introduction of its Guidelines for Drinking-Water Quality in 1984, the WHO Regional Office for Europe was approached by the Government of Italy to develop, as a matter of urgency, recommendations for guidelines levels of certain herbicides found in drinking water supplies. Realizing the extent of the problem, the Regional Office for Europe organized two consultations to develop drinking water quality guidelines for the following 11 herbicides most commonly used in Italy: alachlor, metolachlor, pyridate, atrazine, molinate, simazine, bentazon, pendimethalin, trifluralin, MCPA and propanil. The presence of these and other herbicides in ground and surface water has been reported in several countries. Although the main purpose of these guidelines is to provide guidance to the Government of Italy in making risk management decisions, the information given was also intended to assist the other countries of the European Region in setting standards or in developing alternative control procedures where the implementation of standards is not feasible. The purpose of this paper is to review the process of health risk assessment used in the development of the WHO drinking water quality guidelines for selected herbicides. It will also reveal the major dilemmas and concerns expressed by the participating experts during the process of scientific deliberations, in the interests of understanding the complex issues involved in reaching the bare figures of the recommended guidelines.
1984年成功推出《饮用水质量准则》之后,意大利政府与世界卫生组织欧洲区域办事处接洽,迫切要求针对饮用水供应中发现的某些除草剂制定准则水平建议。欧洲区域办事处认识到问题的严重性,组织了两次磋商会,以制定意大利最常用的以下11种除草剂的饮用水质量准则:甲草胺、异丙甲草胺、哒草酯、莠去津、禾草敌、西玛津、灭草松、二甲戊灵、氟乐灵、2甲4氯和敌稗。几个国家都报告了地表水和地下水中存在这些及其他除草剂的情况。虽然这些准则的主要目的是为意大利政府做出风险管理决策提供指导,但所提供的信息也旨在协助欧洲区域的其他国家制定标准,或在无法实施标准的情况下制定替代控制程序。本文的目的是回顾世界卫生组织选定除草剂饮用水质量准则制定过程中所采用的健康风险评估过程。这也将揭示参与专家在科学审议过程中表达的主要困境和关切,以便了解在得出建议准则的具体数字过程中所涉及的复杂问题。