皮肤伤口愈合的猪模型。
Porcine models of cutaneous wound healing.
作者信息
Seaton Max, Hocking Anne, Gibran Nicole S
机构信息
Max Seaton, MD, is a general surgery resident at the University of Maryland Medical Center in Baltimore, Maryland, and a research fellow in the Department of Surgery at the University of Washington, in Seattle, Washington. Anne Hocking, PhD, is a research associate professor in the Department of Surgery at the University of Washington. Nicole S. Gibran, MD, FACS, is a professor in the Department of Surgery at the University of Washington and Director of the Burn Center at Harborview Medical Center, in Seattle, Washington.
出版信息
ILAR J. 2015;56(1):127-38. doi: 10.1093/ilar/ilv016.
Cutaneous wound healing in the pig is frequently used as a model for human cutaneous wound healing. In this review, we examine the appropriateness of this model for studying normal and pathological wound healing, and describe models for chronic nonhealing wounds, diabetic wounds, burns, and hypertrophic scars. In addition, we focus on studies that have used pigs to evaluate wound-healing therapies, and discuss genetic engineering technology in the pig that may advance our knowledge of wound healing. We conclude that, although not perfect, the pig offers a versatile model that can be adjusted to mimic a wide range of clinical scenarios.
猪的皮肤伤口愈合常被用作人类皮肤伤口愈合的模型。在本综述中，我们研究了该模型用于研究正常和病理性伤口愈合的适用性，并描述了慢性不愈合伤口、糖尿病伤口、烧伤和增生性瘢痕的模型。此外，我们重点关注了利用猪来评估伤口愈合疗法的研究，并讨论了猪的基因工程技术，该技术可能会增进我们对伤口愈合的了解。我们得出结论，尽管并不完美，但猪提供了一个通用模型，可以进行调整以模拟广泛的临床情况。
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