活跃的棕色脂肪组织在癌症恶病质中起作用吗？
A role of active brown adipose tissue in cancer cachexia?
作者信息
Beijer Emiel, Schoenmakers Janna, Vijgen Guy, Kessels Fons, Dingemans Anne-Marie, Schrauwen Patrick, Wouters Miel, van Marken Lichtenbelt Wouter, Teule Jaap, Brans Boudewijn
机构信息
Departments of Nuclear Medicine.
Respiratory.
出版信息
Oncol Rev. 2012 Jun 12;6(1):e11. doi: 10.4081/oncol.2012.e11. eCollection 2012 Mar 5.
Abstract
Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT). Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energetic pathways. White, brown and so-called brite adipose fat seem to be able to trans-differentiate into each other, emphasizing the dynamic nature of fat tissue for metabolism. Human and animal data in cancer cachexia to date provide some evidence for BAT activation, but its quantitative impact on energy expenditure and weight loss is controversial. Prospective clinical studies can address the potential role of BAT in cancer cachexia using (18)F-fluoro- deoxyglucose positron emission tomography-computed tomography scanning, with careful consideration of co-factors such as diet, exposure to the cold, physical activity and body mass index, that all seem to act on BAT recruitment and activity.
摘要
直到几年前，人们还认为成年人体内不存在棕色脂肪组织（BAT）。如今，这是一个快速发展的研究领域，在肥胖等代谢综合征以及针对其生物能量途径的新疗法方面都有相关研究视角。白色脂肪、棕色脂肪以及所谓的米色脂肪似乎能够相互转分化，这凸显了脂肪组织在新陈代谢方面的动态特性。迄今为止，关于癌症恶病质的人类和动物数据为棕色脂肪组织的激活提供了一些证据，但其对能量消耗和体重减轻的定量影响仍存在争议。前瞻性临床研究可以通过（18）F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描来探究棕色脂肪组织在癌症恶病质中的潜在作用，同时要仔细考虑饮食、寒冷暴露、身体活动和体重指数等共同因素，这些因素似乎都会对棕色脂肪组织的募集和活性产生影响。
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