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血液透析的自我动静脉内瘘穿刺:患者特征、临床关联及自我动静脉内瘘穿刺偏好模型

Self-cannulation for haemodialysis: patient attributes, clinical correlates and self-cannulation predilection models.

作者信息

Jayanti Anuradha, Foden Philip, Wearden Alison, Morris Julie, Brenchley Paul, Mitra Sandip

机构信息

Department of Nephrology, Central Manchester Hospitals NHS Trust, Manchester, United Kingdom.

Department of Biostatistics, University of Manchester, Manchester, United Kingdom.

出版信息

PLoS One. 2015 May 19;10(5):e0125606. doi: 10.1371/journal.pone.0125606. eCollection 2015.

Abstract

BACKGROUND AND OBJECTIVES

With emerging evidence in support of home haemodialysis (HHD), patient factors which determine uptake of the modality need to be better understood. Self-cannulation (SC) is a major step towards enabling self-care 'in-centre' and at home and remains the foremost barrier to its uptake. Human factors governing this aspect of HD practice are poorly understood. The aim of this study is to better understand self-cannulation preferences and factors which define them in end stage renal disease (ESRD).

DESIGN

In this multicentre study, 508 of 535 patients from predialysis (Group A: n = 222), in-centre (Group B: n = 213), and home HD (Group C: n = 100) responded to a questionnaire with 3 self-cannulation questions. Simultaneously, data on clinical, cognitive and psychosocial variables were ascertained. The primary outcome measure was 'perceived ability to self-cannulate AV access'. Predictive models were developed using logistic regression analysis.

RESULTS

36.6% of predialysis patients (A) and 29.1% of the 'in-centre' haemodialysis patients (B) felt able to consider SC for HD. Technical-skills related apprehension was highest in Group B (14.4%) patients. Response to routine venepuncture and the types of SC concerns were significant predictors of perceived ability to self-cannulate. There was no significant difference in concern for pain across the groups. In multivariable regression analysis, age, education level, 3 MS score, hypoalbuminemia in Groups B & C and additionally, attitude to routine phlebotomy and the nature of specific concern for self-cannulation in Groups A, B and C, are significant predictors of SC preference. The unadjusted c-statistics of models 1 (derived from Group A and validated on A) and 2 (derived from B+C and validated on B), are 0.76(95% CI 0.69, 0.83) and 0.80 (95% CI 0.74, 0.87) respectively.

CONCLUSIONS

There is high prevalence of perceived ability to self-cannulate. Modifiable SC concerns exist in ESRD. The use of predictive models to objectively define and target education and training strategies could potentially impact on HD self-management and future uptake of home HD.

摘要

背景与目的

随着越来越多的证据支持家庭血液透析(HHD),需要更好地了解决定采用这种治疗方式的患者因素。自我动静脉内瘘穿刺(SC)是实现“中心”和家庭自我护理的重要一步,仍然是采用该方法的首要障碍。人们对血液透析实践中这方面的人为因素了解甚少。本研究的目的是更好地了解终末期肾病(ESRD)患者的自我动静脉内瘘穿刺偏好及其相关因素。

设计

在这项多中心研究中,535名患者中的508名,包括透析前患者(A组:n = 222)、中心血液透析患者(B组:n = 213)和家庭血液透析患者(C组:n = 100),回答了一份包含3个自我动静脉内瘘穿刺问题的问卷。同时,确定了临床、认知和社会心理变量的数据。主要结局指标是“自我动静脉内瘘穿刺的感知能力”。使用逻辑回归分析建立预测模型。

结果

36.6%的透析前患者(A组)和29.1%的“中心”血液透析患者(B组)认为自己能够考虑进行自我动静脉内瘘穿刺。B组患者中与技术技能相关的担忧最高(14.4%)。对常规静脉穿刺的反应和自我动静脉内瘘穿刺担忧的类型是自我动静脉内瘘穿刺感知能力的重要预测因素。各组对疼痛的担忧没有显著差异。在多变量回归分析中,年龄、教育水平、3MS评分、B组和C组的低白蛋白血症,此外,A组、B组和C组对常规静脉穿刺的态度以及对自我动静脉内瘘穿刺的具体担忧性质,都是自我动静脉内瘘穿刺偏好的重要预测因素。模型1(源自A组并在A组验证)和模型2(源自B + C组并在B组验证)的未调整c统计量分别为0.76(95%CI 0.69,0.83)和0.80(95%CI 0.74,0.87)。

结论

自我动静脉内瘘穿刺的感知能力普遍较高。ESRD患者存在可改变的自我动静脉内瘘穿刺担忧。使用预测模型客观地定义和确定教育与培训策略,可能会对血液透析自我管理以及未来家庭血液透析的采用产生影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88fd/4437898/c5809204f02c/pone.0125606.g001.jpg

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