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肾脏中心及患者社会人口学因素对英国家庭血液透析普及率的影响

The Influence of Renal Centre and Patient Sociodemographic Factors on Home Haemodialysis Prevalence in the UK.

作者信息

Jayanti Anuradha, Foden Philip, Rae Alasdair, Morris Julie, Brenchley Paul, Mitra Sandip

机构信息

Department of Nephrology, Central Manchester Hospitals NHS Trust, Manchester, UK.

出版信息

Nephron. 2017;136(2):62-74. doi: 10.1159/000452927. Epub 2017 Feb 9.

Abstract

BACKGROUND

In the United Kingdom, socioeconomic disadvantage has been associated with lower use of home dialysis, mostly peritoneal dialysis. In this study, we explore the role of a patient's sociodemographic, socioeconomic differences and the centre's influence on home haemodialysis (HD) prevalence.

METHODS

Data is derived from the cross-sectional arm of the UK multi-centre study investigating barriers and enablers of home HD (BASIC-HHD study). Centres were classified as low- (<3%), medium- (5-8%) and high-prevalence groups (>8%). Sociodemographic and socioeconomic status data were ascertained. Patients were enrolled in hospital HD (n = 213), home HD (n = 93) and predialysis groups (n = 222).

RESULTS

The treating renal centre to which the patient belonged was significantly associated with a patient's modality in prevalent HD groups and modality-choice in the "predialysis" group, in confounder-adjusted multivariable analyses. Non-white ethnicity was associated with lower odds of self-care dialysis modality choice (OR 0.21, 95% CI 0.07-0.62) and lower odds of home HD uptake in the prevalent HD group (OR 0.24, 95% CI 0.07-0.80). Other significant associations of home HD uptake in the HD cohort included lower age (OR 0.59, 95% CI 0.39-0.89), higher education (OR 2.99, 95% CI 1.25-7.16), home ownership (OR 0.26, 95% CI 0.09-0.70), childcare responsibility (OR 0.22, 95% CI 0.08-0.66) and unrestricted mobility (OR 0.31, 95% CI 0.11-0.91).

CONCLUSION

"Centre" effect accounts for variation in home HD prevalence between renal units after accounting for sociodemographic parameters and co-morbidities. Unit practices and attitudes to home HD are likely to have a dominating impact on home HD prevalence rates and these aspects need to be explored systematically at the organisational level.

摘要

背景

在英国,社会经济劣势与家庭透析(主要是腹膜透析)的低使用率相关。在本研究中,我们探讨患者的社会人口统计学、社会经济差异以及中心对家庭血液透析(HD)患病率的影响。

方法

数据来源于英国多中心研究的横断面部分,该研究调查了家庭HD的障碍和促进因素(BASIC - HHD研究)。中心被分为低患病率组(<3%)、中等患病率组(5 - 8%)和高患病率组(>8%)。确定了社会人口统计学和社会经济状况数据。患者被纳入医院HD组(n = 213)、家庭HD组(n = 93)和透析前组(n = 222)。

结果

在经过混杂因素调整的多变量分析中,患者所属的治疗肾脏中心与HD现患率组患者的透析方式以及“透析前”组患者的透析方式选择显著相关。非白人种族与自我护理透析方式选择的较低几率(OR 0.21,95% CI 0.07 - 0.62)以及HD现患率组中家庭HD接受率的较低几率(OR 0.24,95% CI 0.07 - 0.80)相关。HD队列中家庭HD接受率的其他显著相关因素包括较低年龄(OR 0.59,95% CI 0.39 - 0.89)、较高教育程度(OR 2.99,95% CI 1.25 - 7.16)、自有住房(OR 0.26,95% CI 0.09 - 0.70)、育儿责任(OR 0.22,95% CI 0.08 - 0.66)和行动不受限制(OR 0.31,95% CI 0.11 - 0.91)。

结论

在考虑社会人口统计学参数和合并症后,“中心”效应解释了肾脏单位之间家庭HD患病率的差异。单位对家庭HD的实践和态度可能对家庭HD患病率有主导影响,这些方面需要在组织层面进行系统探索。

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