Jayanti Anuradha, Foden Philip, Rae Alasdair, Morris Julie, Brenchley Paul, Mitra Sandip
Department of Nephrology, Central Manchester Hospitals NHS Trust, Manchester, UK.
Nephron. 2017;136(2):62-74. doi: 10.1159/000452927. Epub 2017 Feb 9.
In the United Kingdom, socioeconomic disadvantage has been associated with lower use of home dialysis, mostly peritoneal dialysis. In this study, we explore the role of a patient's sociodemographic, socioeconomic differences and the centre's influence on home haemodialysis (HD) prevalence.
Data is derived from the cross-sectional arm of the UK multi-centre study investigating barriers and enablers of home HD (BASIC-HHD study). Centres were classified as low- (<3%), medium- (5-8%) and high-prevalence groups (>8%). Sociodemographic and socioeconomic status data were ascertained. Patients were enrolled in hospital HD (n = 213), home HD (n = 93) and predialysis groups (n = 222).
The treating renal centre to which the patient belonged was significantly associated with a patient's modality in prevalent HD groups and modality-choice in the "predialysis" group, in confounder-adjusted multivariable analyses. Non-white ethnicity was associated with lower odds of self-care dialysis modality choice (OR 0.21, 95% CI 0.07-0.62) and lower odds of home HD uptake in the prevalent HD group (OR 0.24, 95% CI 0.07-0.80). Other significant associations of home HD uptake in the HD cohort included lower age (OR 0.59, 95% CI 0.39-0.89), higher education (OR 2.99, 95% CI 1.25-7.16), home ownership (OR 0.26, 95% CI 0.09-0.70), childcare responsibility (OR 0.22, 95% CI 0.08-0.66) and unrestricted mobility (OR 0.31, 95% CI 0.11-0.91).
"Centre" effect accounts for variation in home HD prevalence between renal units after accounting for sociodemographic parameters and co-morbidities. Unit practices and attitudes to home HD are likely to have a dominating impact on home HD prevalence rates and these aspects need to be explored systematically at the organisational level.
在英国,社会经济劣势与家庭透析(主要是腹膜透析)的低使用率相关。在本研究中,我们探讨患者的社会人口统计学、社会经济差异以及中心对家庭血液透析(HD)患病率的影响。
数据来源于英国多中心研究的横断面部分,该研究调查了家庭HD的障碍和促进因素(BASIC - HHD研究)。中心被分为低患病率组(<3%)、中等患病率组(5 - 8%)和高患病率组(>8%)。确定了社会人口统计学和社会经济状况数据。患者被纳入医院HD组(n = 213)、家庭HD组(n = 93)和透析前组(n = 222)。
在经过混杂因素调整的多变量分析中,患者所属的治疗肾脏中心与HD现患率组患者的透析方式以及“透析前”组患者的透析方式选择显著相关。非白人种族与自我护理透析方式选择的较低几率(OR 0.21,95% CI 0.07 - 0.62)以及HD现患率组中家庭HD接受率的较低几率(OR 0.24,95% CI 0.07 - 0.80)相关。HD队列中家庭HD接受率的其他显著相关因素包括较低年龄(OR 0.59,95% CI 0.39 - 0.89)、较高教育程度(OR 2.99,95% CI 1.25 - 7.16)、自有住房(OR 0.26,95% CI 0.09 - 0.70)、育儿责任(OR 0.22,95% CI 0.08 - 0.66)和行动不受限制(OR 0.31,95% CI 0.11 - 0.91)。
在考虑社会人口统计学参数和合并症后,“中心”效应解释了肾脏单位之间家庭HD患病率的差异。单位对家庭HD的实践和态度可能对家庭HD患病率有主导影响,这些方面需要在组织层面进行系统探索。