Frankfurt Maya, Luine Victoria
Department of Science Education, Hofstra-North Shore LIJ School of Medicine, USA.
Department of Psychology, Hunter College of CUNY, USA.
Horm Behav. 2015 Aug;74:28-36. doi: 10.1016/j.yhbeh.2015.05.004. Epub 2015 May 17.
This article is part of a Special Issue "Estradiol and Cognition". Memory processing is presumed to depend on synaptic plasticity, which appears to have a role in mediating the acquisition, consolidation, and retention of memory. We have studied the relationship between estrogen, recognition memory, and dendritic spine density in the hippocampus and medial prefrontal cortex, areas critical for memory, across the lifespan in female rodents. The present paper reviews the literature on dendritic spine plasticity in mediating both short and long term memory, as well as the decreased memory that occurs with aging and Alzheimer's disease. It also addresses the role of acute and chronic estrogen treatments in these processes.
本文是《雌二醇与认知》特刊的一部分。记忆处理被认为依赖于突触可塑性，而突触可塑性似乎在介导记忆的获取、巩固和保持方面发挥作用。我们研究了雌性啮齿动物在整个生命周期中，雌激素、识别记忆以及海马体和内侧前额叶皮质（对记忆至关重要的区域）中树突棘密度之间的关系。本文综述了关于树突棘可塑性在介导短期和长期记忆以及衰老和阿尔茨海默病中出现的记忆减退方面的文献。它还探讨了急性和慢性雌激素治疗在这些过程中的作用。
