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本文引用的文献

1
Rapid effects of estrogens on short-term memory: Possible mechanisms.雌激素对短期记忆的快速影响：可能的机制。
Horm Behav. 2018 Aug;104:88-99. doi: 10.1016/j.yhbeh.2018.05.019. Epub 2018 Jun 1.
2
Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.雌激素和孕激素对雌性啮齿动物海马记忆巩固的快速作用的机制。
Horm Behav. 2018 Aug;104:100-110. doi: 10.1016/j.yhbeh.2018.04.013. Epub 2018 May 9.
3
Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females.雌激素受体和代谢型谷氨酸受体的相互作用及其对女性药物成瘾的影响。
Horm Behav. 2018 Aug;104:130-137. doi: 10.1016/j.yhbeh.2018.03.001. Epub 2018 Mar 10.
4
Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid.神经甾体对海马树突棘的快速非基因组调节：雄激素、雌激素和皮质类固醇。
J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12561.
5
Estradiol rapidly increases GluA2-mushroom spines and decreases GluA2-filopodia spines in hippocampus CA1.雌二醇迅速增加海马 CA1 区的 GluA2 蘑菇状棘突，并减少 GluA2 丝状棘突。
Hippocampus. 2017 Dec;27(12):1224-1229. doi: 10.1002/hipo.22768. Epub 2017 Aug 28.
6
Rapid actions of oestrogens and their receptors on memory acquisition and consolidation in females.雌激素及其受体对女性记忆获得和巩固的快速作用。
J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12485.
7
Neuroendocrine Networks and Functionality.神经内分泌网络与功能
Psychiatr Clin North Am. 2017 Jun;40(2):189-200. doi: 10.1016/j.psc.2017.01.008. Epub 2017 Mar 18.
8
Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice.抑制海马体中的局部雌激素合成会损害去卵巢雌性小鼠的海马体记忆巩固。
Horm Behav. 2016 Jul;83:60-67. doi: 10.1016/j.yhbeh.2016.05.001. Epub 2016 May 10.
9
17β-Estradiol and Agonism of G-protein-Coupled Estrogen Receptor Enhance Hippocampal Memory via Different Cell-Signaling Mechanisms.17β-雌二醇与G蛋白偶联雌激素受体激动作用通过不同细胞信号机制增强海马体记忆。
J Neurosci. 2016 Mar 16;36(11):3309-21. doi: 10.1523/JNEUROSCI.0257-15.2016.
10
17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females.17β-雌二醇通过不同机制急性增强雄性和雌性海马中的谷氨酸能突触传递。
J Neurosci. 2016 Mar 2;36(9):2677-90. doi: 10.1523/JNEUROSCI.4437-15.2016.

雌激素对雌性和雄性啮齿动物记忆巩固和脊柱形态的快速影响。

Rapid effects on memory consolidation and spine morphology by estradiol in female and male rodents.

机构信息

Department of Psychology, Hunter College of CUNY, New York, NY, USA.

Department of Psychology, Hunter College of CUNY, New York, NY, USA.

出版信息

Horm Behav. 2018 Aug;104:111-118. doi: 10.1016/j.yhbeh.2018.04.007. Epub 2018 May 31.

DOI:10.1016/j.yhbeh.2018.04.007
PMID:29669258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6274598/
Abstract

Contribution to Special Issue on Fast effects of steroids. Rapid, neurosteroid-like effects of estrogens on memory consolidation during recognition memory tasks in both male and female rodents are described. We discuss how these mnemonic changes are related to rapid estrogenic effects on dendritic spine density, the distribution of spine types and the expression of PSD95 and GluA2 within spines in the hippocampus and medial prefrontal cortex, two areas critical for learning and memory. Overall, these data lead to the conclusion that estrogens are capable of exerting rapid and potent influences on memory and spine morphology in both sexes. The demonstration of estrogenic effects in males, which are used in the majority of memory studies, may provide a model for better understanding how hormone dependent changes in signaling pathways mediating memory and spinogenesis are coordinated to promote memory consolidation.

摘要

快速作用的类固醇。本文描述了雌激素在雄性和雌性啮齿动物的识别记忆任务中对记忆巩固的快速、类神经甾体样作用。我们讨论了这些记忆变化如何与雌激素对树突棘密度、棘突类型分布以及海马和内侧前额叶皮质中 PSD95 和 GluA2 在棘突内表达的快速影响相关，这两个区域对学习和记忆至关重要。总的来说，这些数据得出的结论是，雌激素能够在两性中对记忆和脊柱形态产生快速而强大的影响。在大多数记忆研究中使用的雄性动物中雌激素作用的证明，可能为更好地理解调节记忆和棘突发生的信号通路中的激素依赖性变化如何协调以促进记忆巩固提供了一个模型。