家蚕幼虫（Bombyx mori）在药物医学研究中作为动物模型的当前应用。
Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research.
作者信息
Nwibo Don Daniel, Hamamoto Hiroshi, Matsumoto Yasuhiko, Kaito Chikara, Sekimizu Kazuhisa
机构信息
Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
出版信息
Drug Discov Ther. 2015 Apr;9(2):133-5. doi: 10.5582/ddt.2015.01026.
We advocate the use of silkworm larvae, Bombyx mori, as an animal model for discovery of drug candidates. We have established several disease models using silkworms, which offer technical advantages in drug development and the study of host-pathogen interaction. This mini review briefly describes recent trends in the use of silkworm larvae as a non-mammalian model for drug discovery and it offers suggestions regarding the potential for silkworm use in pharmaceutical-biomedical research.
我们提倡将家蚕（Bombyx mori）幼虫用作发现候选药物的动物模型。我们已经利用家蚕建立了多种疾病模型，这些模型在药物开发以及宿主-病原体相互作用研究方面具有技术优势。这篇小型综述简要描述了将家蚕幼虫用作非哺乳动物药物发现模型的最新趋势，并就家蚕在制药-生物医学研究中的应用潜力提出了建议。
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