Frazier Nick, Ghandehari Hamidreza
Department of Bioengineering, University of Utah, 36 S. Wasatch Dr., Salt Lake City, Utah, 84112.
Center for Nanomedicine, Nano Institute of Utah, University of Utah, 36 S. Wasatch Dr., Salt Lake City, Utah, 84112.
Biotechnol Bioeng. 2015 Oct;112(10):1967-83. doi: 10.1002/bit.25653. Epub 2015 Jul 14.
Drug delivery to solid tumors has received much attention in order to reduce harmful side effects and improve the efficacy of treatment. Different strategies have been utilized with nanoparticle drug delivery systems, or nanomedicines, including passive and active targeting strategies, as well as the incorporation of stimuli sensitivity. Additionally, hyperthermia has been used in combination with such systems to further improve accumulation, localization, penetration, and subsequently efficacy. Localized hyperthermia within the solid tumor tissue can be applied through different mechanisms able to trigger vascular and cellular mechanisms for enhanced delivery of nanomedicines. This review covers the use of nanoparticles in drug delivery, the different methods for inducing localized hyperthermia, combination effects of hyperthermia, and successful strategies for improving the delivery of nanomedicines using hyperthermia.
为了减少有害副作用并提高治疗效果，向实体瘤给药备受关注。纳米颗粒药物递送系统（即纳米药物）已采用了不同策略，包括被动和主动靶向策略，以及引入刺激敏感性。此外，热疗已与此类系统联合使用，以进一步改善纳米药物的蓄积、定位、渗透，并进而提高疗效。实体瘤组织内的局部热疗可通过不同机制实现，这些机制能够触发血管和细胞机制，以增强纳米药物的递送。本综述涵盖了纳米颗粒在药物递送中的应用、诱导局部热疗的不同方法、热疗的联合效应，以及利用热疗改善纳米药物递送的成功策略。
