École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux et Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, CH-1015, Lausanne, Switzerland.
Macromol Biosci. 2017 Oct;17(10). doi: 10.1002/mabi.201700022. Epub 2017 Apr 26.
Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer-based nanocarriers allow to increase plasma half-life and drug bioavailability and can also be guided toward tumors using passive and active targeting strategies. Since many chemotherapeutics act on targets that are located in well-defined subcellular compartments, other important factors that contribute to an efficient therapy include cellular internalization and subsequent intracellular trafficking of the polymer nanomedicines and/or its payload to the appropriate organelle in the cytoplasm. This article provides an overview of the different approaches that have been developed to control intracellular delivery of polymer nanomedicines and discusses the different techniques that can be used to monitor these processes.
聚合物纳米药物在提高化疗药物的递送方面非常有吸引力。聚合物缀合物和其他基于聚合物的纳米载体可以增加血浆半衰期和药物生物利用度，并且还可以使用被动和主动靶向策略引导至肿瘤。由于许多化疗药物作用于位于明确的亚细胞隔室中的靶标，因此有助于有效治疗的其他重要因素包括聚合物纳米药物及其有效负载物向细胞质中适当细胞器的细胞内化和随后的细胞内转运。本文综述了控制聚合物纳米药物细胞内递送的不同方法，并讨论了可用于监测这些过程的不同技术。
