Hess Jeannine, Keiser Jennifer, Gasser Gilles
Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Future Med Chem. 2015;7(6):821-30. doi: 10.4155/fmc.15.22.
In the recent years, there has been a growing interest in the use of novel approaches for the treatment of parasitic diseases such as schistosomiasis. Among the different approaches used, organometallic compounds were found to offer unique opportunities in the design of antiparasitic drug candidates. A ferrocenyl derivative, namely ferroquine, has even entered clinical trials as a novel antimalarial. In this short review, we report on the studies describing the use of organometallic compounds against schistosomiasis.
近年来，人们对使用新方法治疗血吸虫病等寄生虫病的兴趣日益浓厚。在所使用的不同方法中，发现有机金属化合物在设计抗寄生虫候选药物方面提供了独特的机会。一种二茂铁基衍生物，即二茂铁喹，甚至已作为一种新型抗疟药进入临床试验阶段。在这篇简短的综述中，我们报告了描述使用有机金属化合物治疗血吸虫病的研究。
