Schneider Angelika E, Manolikakes Georg
Department of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt am Main D-60438, Germany.
J Org Chem. 2015 Jun 19;80(12):6193-212. doi: 10.1021/acs.joc.5b00662. Epub 2015 Jun 1.
A bismuth(III) triflate catalyzed three-component synthesis of α-substituted amides starting from amides, aldehydes, and (hetero)arenes is reported. The reaction has a broad substrate scope, encompassing formaldehyde as well as aryl and alkyl aldehydes. Low catalyst loadings are required, and water is formed as the only side product. The scope and limitation of this method will be discussed.
报道了一种由三氟甲磺酸铋（III）催化，从酰胺、醛和（杂）芳烃出发合成α-取代酰胺的三组分反应。该反应底物范围广泛，包括甲醛以及芳基和烷基醛。所需催化剂负载量低，且仅生成水作为唯一的副产物。将讨论该方法的适用范围和局限性。
