Zheng Yin, Wang Youming, Zhou Zhenghong
Institute and State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering Nankai University, Tianjin 300071, P. R. China.
Chem Commun (Camb). 2015 Dec 4;51(93):16652-5. doi: 10.1039/c5cc05624a. Epub 2015 Oct 1.
We have developed an organocatalyzed three-component reaction of 1,2-diones, aldehydes and arylamines, which provides an efficient approach to access polysubstituted pyrroles. In the catalysis of 4-methylbenzenesulfonic acid monohydrate, the reactions of a wide range of 1,2-diones, arylamines and aldehydes took place smoothly to generate the corresponding polysubstituted pyrroles in acceptable to good yields under mild reaction conditions.
我们已经开发了一种1,2 - 二酮、醛和芳胺的有机催化三组分反应，该反应为合成多取代吡咯提供了一种有效方法。在一水合对甲基苯磺酸的催化下，多种1,2 - 二酮、芳胺和醛顺利发生反应，在温和的反应条件下以可接受至良好的产率生成相应的多取代吡咯。
