Li Zejiang, Xiao Yingxia, Liu Zhong-Quan
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, P. R. China.
Chem Commun (Camb). 2015 Jun 21;51(49):9969-71. doi: 10.1039/c5cc02968f.
An efficient hydrocyanoalkylation of unactivated alkenes with alkyl nitriles was developed. Through this free-radical-initiated selective activation of the α-C(sp(3))-H bond of acetonitriles, an anti-Markovnikov addition of an α-cyano C-centered radical to olefins has been achieved, which allows a facile and convenient access to functionalized nitriles in large scales.
开发了一种未活化烯烃与烷基腈的高效氢氰基烷基化反应。通过这种自由基引发的乙腈α-C(sp(3))-H键的选择性活化，实现了α-氰基C中心自由基对烯烃的反马氏加成，从而能够大规模便捷地获得官能化腈类化合物。
