早产婴儿二十二碳六烯酸（DHA）剂量反应随机对照试验。
A dose response randomised controlled trial of docosahexaenoic acid (DHA) in preterm infants.
作者信息
Collins C T, Sullivan T R, McPhee A J, Stark M J, Makrides M, Gibson R A
机构信息
Child Nutrition and FOODplus Research Centres, Women׳s and Children׳s Health Research Institute, Flinders Medical Centre, Women׳s and Children׳s Hospital and The University of Adelaide, South Australia, Australia; Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; School of Paediatrics and Reproductive Health, The University of Adelaide, South Australia.
School of Population Health, The University of Adelaide, Adelaide, South Australia, Australia.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2015 Aug;99:1-6. doi: 10.1016/j.plefa.2015.04.003. Epub 2015 Apr 15.
Thirty one infants born less than 30 weeks׳ gestational age were randomised to receive either 40 (n=11), 80 (n=9) or 120 (n=11) mg/kg/day of docosahexaenoic acid (DHA) respectively as an emulsion, via the feeding tube, commenced within 4 days of the first enteral feed. Twenty three infants were enroled in non-randomised reference groups; n=11 who had no supplementary DHA and n=12 who had maternal DHA supplementation. All levels of DHA in the emulsion were well tolerated with no effect on number of days of interrupted feeds or days to full enteral feeds. DHA levels in diets were directly related to blood DHA levels but were unrelated to arachidonic acid (AA) levels. All randomised groups and the maternal supplementation reference group prevented the drop in DHA levels at study end that was evident in infants not receiving supplementation. Australian New Zealand Clinical Trials Registry: ACTRN12610000382077.
31名孕周小于30周的婴儿被随机分组，分别通过喂养管接受40（n = 11）、80（n = 9）或120（n = 11）mg/kg/天的二十二碳六烯酸（DHA）乳剂，在首次肠内喂养的4天内开始。23名婴儿被纳入非随机参照组；11名未补充DHA，12名母亲补充了DHA。乳剂中所有水平的DHA耐受性良好，对喂养中断天数或完全肠内喂养天数均无影响。饮食中的DHA水平与血液中的DHA水平直接相关，但与花生四烯酸（AA）水平无关。所有随机分组组和母亲补充DHA的参照组均防止了研究结束时DHA水平的下降，这在未接受补充剂的婴儿中很明显。澳大利亚新西兰临床试验注册中心：ACTRN12610000382077。
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