早产儿的脂质和长链多不饱和脂肪酸。
Lipids and Long Chain Polyunsaturated Fatty Acids in Preterm Infants.
机构信息
Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA; Department of Neonatology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Rose3, Boston, MA 02215, USA.
出版信息
Clin Perinatol. 2022 Jun;49(2):381-391. doi: 10.1016/j.clp.2022.02.007. Epub 2022 Apr 21.
Abstract
Fatty acids are critical bioactives for fetal and neonatal development. Premature delivery and current nutritional strategies pose several challenges in restoring fatty acid balance in the preterm infant. The impact on fatty acid balance and outcomes using lipid emulsions, enteral nutrition, and enteral supplements are reviewed, including a summary of the most recent large clinical trials of enteral fatty acid supplementation for the preterm infant. Research gaps remain in successfully implementing nutritional strategies to optimize fatty acid status in preterm infants.
摘要
脂肪酸是胎儿和新生儿发育的关键生物活性物质。早产和当前的营养策略给早产儿体内脂肪酸平衡的恢复带来了诸多挑战。本文对脂类乳剂、肠内营养和肠内补充剂在维持脂肪酸平衡和改善结局方面的影响进行了综述，包括对近期早产儿肠内补充脂肪酸的大型临床试验的总结。在成功实施营养策略以优化早产儿脂肪酸状态方面，仍存在研究空白。
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