Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Central University, Sagar, MP 470 003, India; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Central University, Sagar, MP 470 003, India.
Drug Discov Today. 2015 Sep;20(9):1049-60. doi: 10.1016/j.drudis.2015.05.004. Epub 2015 May 19.
Recent years have witnessed the booming development of carbon nanotubes (CNTs) and their composites in biological and medicine. By virtue of their unique physicochemical properties, CNTs have emerged as potential tools in biomedical applications as a result of their development as safe, effective nanomedicines. Diverse cell lines have been shown to be best-fit experimental models for evaluating the pharmacokinetic parameters, cell viability, and cytotoxicity of CNTS, as well as their drug efficacy ex vivo, which can then be correlated with their in vivo performance. The biological activities and cytotoxic effects of CNTs are dependent on their surface chemistry, and how they are purified and functionalized. Here, we focus on aspects of CNTs including their functionalization, and their biomedical potential and limitations, emphasizing the toxicological aspects of functionalized CNTs using various cell lines. The outlook for CNT-based nanomedicine, particularly in cancer treatment, is fascinating and encouraging. In vitro cell line data can assist the selection of specific cancer cell lines for the evaluation of anticancer bioactive-loaded CNTs as a novel drug delivery tool in the diagnosis and treatment of cancer.
近年来，碳纳米管（CNTs）及其复合材料在生物和医学领域得到了蓬勃发展。由于其具有独特的物理化学性质，CNTs 已成为安全、有效的纳米药物，因此有望成为生物医学应用的潜在工具。不同的细胞系被证明是评估 CNTs 的药代动力学参数、细胞活力和细胞毒性以及它们在体外的药效的最佳实验模型，然后可以将这些参数与它们的体内性能相关联。CNTs 的生物活性和细胞毒性取决于它们的表面化学性质，以及它们的纯化和功能化方式。在这里，我们重点介绍 CNTs 的功能化及其在生物医学中的潜在应用和局限性，强调使用各种细胞系研究功能化 CNTs 的毒理学方面。基于 CNT 的纳米医学的前景，特别是在癌症治疗方面，非常吸引人且令人鼓舞。体外细胞系数据可以帮助选择特定的癌细胞系，用于评估作为癌症诊断和治疗新型药物递送工具的负载抗癌生物活性物质的 CNTs。
