Cassano Domenico, Rota Martir Diego, Signore Giovanni, Piazza Vincenzo, Voliani Valerio
Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12 - 56126, Pisa (PI), Italy.
Chem Commun (Camb). 2015 Jun 21;51(49):9939-41. doi: 10.1039/c5cc02771c.
We introduce biodegradable hollow silica nanocapsules embedding arrays of 3 nm gold nanoparticles. The silica shell degrades in full serum in a few hours, potentially allowing the clearance of the capsules and their contents by the efficient renal pathway, and thereby overcoming accumulation issues typical of metal nanoparticles.
我们引入了包埋有3纳米金纳米颗粒阵列的可生物降解中空二氧化硅纳米胶囊。二氧化硅壳层在全血清中几小时内就会降解，这有可能使纳米胶囊及其内容物通过高效的肾脏途径被清除，从而克服金属纳米颗粒典型的积累问题。
