McGrory Sarah, Starr John M, Shenkin Susan D, Austin Elizabeth J, Hodges John R
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK ; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK ; Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Dement Geriatr Cogn Dis Extra. 2015 Apr 15;5(1):155-69. doi: 10.1159/000375364. eCollection 2015 Jan-Apr.
The Addenbrooke's Cognitive Examination (ACE) is used to measure cognition across a range of domains in dementia. Identifying the order in which cognitive decline occurs across items, and whether this varies between dementia aetiologies could add more information to subdomain scores.
ACE-Revised data from 350 patients were split into three groups: Alzheimer's type (n = 131), predominantly frontal (n = 119) and other frontotemporal lobe degenerative disorders (n = 100). Results of factor analysis and Mokken scaling analysis were compared.
Principal component analysis revealed one factor for each group. Confirmatory factor analysis found that the one-factor model fit two samples poorly. Mokken analyses revealed different item ordering in terms of difficulty for each group.
The different patterns for each diagnostic group could aid in the separation of these different types of dementia.
剑桥认知功能量表（ACE）用于测量痴呆症患者多个领域的认知功能。确定各个项目认知衰退发生的顺序，以及这种顺序在不同病因的痴呆症中是否存在差异，可能会为子领域得分增加更多信息。
将350例患者的ACE修订版数据分为三组：阿尔茨海默病型（n = 131）、主要为额叶型（n = 119）和其他额颞叶变性疾病（n = 100）。比较因子分析和莫肯量表分析的结果。
主成分分析显示每组各有一个因子。验证性因子分析发现单因子模型对两个样本的拟合效果较差。莫肯分析显示每组在难度方面的项目排序不同。
每个诊断组的不同模式有助于区分这些不同类型的痴呆症。
