Na Kyung-Sun, Han Kyungdo, Park Yong-Gyu, Na Chul, Joo Choun-Ki
*Departmemt of Ophthalmology, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea; †Department of Biostatistics, The Catholic University of Korea, Seoul, Korea; ‡Department of Neuropsychiatry, College of Medicine, Chung-Ang University Medical Center, Seoul, Korea; and §Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Cornea. 2015 Jul;34(7):733-8. doi: 10.1097/ICO.0000000000000464.
To determine the relationship between dry eye disease (DED) and depressive symptoms in a nationally representative sample of Korean women.
This population-based cross-sectional study comprised 6655 women (aged 19 years or older) participating in the fifth annual Korea National Health and Nutrition Examination Survey from 2010 to 2011. Psychological problems associated with clinically diagnosed DED by ophthalmologists and symptoms of DED were assessed using questionnaires and surveys. Data were analyzed using logistic regression to determine the association of depression with allergic disease while controlling for age, lifestyle factors, and medical factors.
Among the participants, the prevalence of clinically diagnosed DED and its symptoms was 12.3% and 20.0%, respectively. Subjects with the diagnosis had a higher likelihood of experiencing severe psychological stress [odds ratio (OR), 2.5; 95% confidential interval (CI), 1.6-4.0], depressive mood (OR, 1.5; 95% CI, 1.1-2.0), anxiety/depression problems (OR, 1.5; 95% CI, 1.1-2.0) and tended to have a history of psychological counseling (OR, 1.8; 95% CI, 1.0-3.1). Subjects with symptoms of DED showed similar patterns.
There is a close association between depression, stress, and DED in women who have been clinically diagnosed with it or those presenting with its symptoms.
在具有全国代表性的韩国女性样本中确定干眼病（DED）与抑郁症状之间的关系。
这项基于人群的横断面研究纳入了6655名年龄在19岁及以上的女性，她们参与了2010年至2011年的第五次韩国年度全国健康与营养检查调查。通过问卷调查评估与眼科医生临床诊断的DED相关的心理问题以及DED症状。使用逻辑回归分析数据，以确定在控制年龄、生活方式因素和医疗因素的情况下抑郁症与过敏性疾病之间的关联。
在参与者中，临床诊断的DED及其症状的患病率分别为12.3%和20.0%。被诊断出患有DED的受试者经历严重心理压力的可能性更高[比值比（OR），2.5；95%置信区间（CI），1.6 - 4.0]，有抑郁情绪（OR，1.5；95% CI，1.1 - 2.0），存在焦虑/抑郁问题（OR，1.5；95% CI，1.1 - 2.0），并且往往有心理咨询史（OR，1.8；95% CI，1.0 - 3.1）。有DED症状的受试者表现出类似的模式。
在临床诊断患有DED或有DED症状的女性中，抑郁、压力与DED之间存在密切关联。
