Seignemartin Crystianne Pacheco, Miranda Milton E, Luz João Gualberto C, Teixeira Rubens G
Professor, Department of Maxillofacial Prosthodontics, Fundação Oncocentro de São Paulo, São Paulo, Brazil.
Professor, Prosthodontic Department, School of Dentistry, São Leoplodo Mandic, Campinas, Brazil.
J Oral Maxillofac Surg. 2015 Oct;73(10):2040-8. doi: 10.1016/j.joms.2015.04.031. Epub 2015 May 8.
Maxillary malignant tumor resection by maxillectomy might lead to defects that can be repaired by prosthetic obturation. The aim of this study was to associate quality of life (QoL) and the Obturator Functioning Scale (OFS) with functional performance and salivary flow rate in Brazilian patients rehabilitated with an obturator prosthesis.
This retrospective cross-sectional study included patients who underwent surgical resection with or without radiotherapy or without chemotherapy and the rehabilitation with an obturator prosthesis at the Fundação Oncocentro de São Paulo (São Paulo, Brazil). The predictor variables were Performance Status Scale for Head and Neck Cancer Patients (PSS-HN) domains and clinical evaluation of salivary flow rate. The outcome variables were overall scores obtained by the University of Washington QoL Scale (UWQOL) and the OFS. Sociodemographics (gender and age) and clinical characteristics (postoperative radiotherapy, tumor stage, classification of maxillary defect, tooth in maxilla, and type of obturator) also were evaluated. Univariate and multivariate analyses were performed to determinate whether PSS-HN domains and salivary flow were predictors of overall QoL and overall OFS.
The sample was composed of 73 patients with a mean age of 62 years and 51% were men. According to the PSS-HN domains, some patients (5%) always ate alone, 87% reported that speech is usually or always understandable, and 56% had no dietary restrictions. Sixty-one patients (65%) reported some degree of hyposalivation. The mean overall QoL score was 76.5 (standard deviation, 5.3). Patients with compromised PSS-HN domains had significantly worse overall UWQOL scores (P = .001, P < .001, and P = .006, respectively). In multiple regression analyses, understandability of speech was the only predictor of overall QoL scores.
The results of this study showed that understandability of speech was the only predictor of overall QoL scores.
通过上颌骨切除术切除上颌恶性肿瘤可能会导致缺损，可通过修复性阻塞器进行修复。本研究的目的是将巴西使用阻塞器假体进行康复治疗的患者的生活质量（QoL）和阻塞器功能量表（OFS）与功能表现和唾液流速相关联。
这项回顾性横断面研究纳入了在巴西圣保罗肿瘤中心接受手术切除（有或无放疗或无化疗）并使用阻塞器假体进行康复治疗的患者。预测变量为头颈癌患者功能状态量表（PSS-HN）各领域以及唾液流速的临床评估。结果变量为华盛顿大学生活质量量表（UWQOL）和OFS获得的总体得分。还评估了社会人口统计学特征（性别和年龄）以及临床特征（术后放疗、肿瘤分期、上颌骨缺损分类、上颌牙齿情况和阻塞器类型）。进行单因素和多因素分析以确定PSS-HN各领域和唾液流速是否为总体QoL和总体OFS的预测因素。
样本由73例患者组成，平均年龄62岁，51%为男性。根据PSS-HN各领域，一些患者（5%）总是独自进食，87%报告言语通常或总是可理解，56%没有饮食限制。61例患者（65%）报告有一定程度的唾液分泌减少。总体QoL平均得分为76.5（标准差，5.3）。PSS-HN各领域受损的患者总体UWQOL得分明显更差（分别为P = .001、P < .001和P = .006）。在多元回归分析中，言语可理解性是总体QoL得分的唯一预测因素。
本研究结果表明，言语可理解性是总体QoL得分的唯一预测因素。
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