Kaluza Joanna, Åkesson Agneta, Wolk Alicja
Department of Human Nutrition, Warsaw University of Life Sciences - SGGW, Warsaw, Poland; Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Int J Cardiol. 2015 Aug 15;193:42-6. doi: 10.1016/j.ijcard.2015.05.044. Epub 2015 May 9.
Epidemiologic studies of red meat consumption in relation to risk of heart failure (HF) are limited. We examined the associations between long-term unprocessed red meat and processed red meat consumption and incidence of HF in women.
The population-based prospective Swedish Mammography Cohort included 34,057 women, aged 48-83 years, with no history of HF or ischemic heart disease at baseline (in 1997). Meat consumption was assessed using a self-administered food-frequency questionnaire (FFQ) in 1997 as well as FFQ administered in 1987-90. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).
During a mean follow-up of 13.2 years, 2806 women were diagnosed with HF. Consumption of processed meat (FFQ 1997) was statistically significant positively associated with HF incidence. Women who consumed ≥ 50 g/day processed red meat compared to those who consumed < 25 g/day had a 1.23 (95% CI: 1.09-1.39, P-trend=0.003) higher risk of HF. Long-term high consumption of processed red meat (average from 1987 to 1997) ≥ 50 g/day in comparison to < 25 g/day was associated with HR: 1.30 (95% CI: 1.05-1.60, P-trend=0.002). Women who consistently consumed (in both 1987 and 1997) ≥ 50 g/day vs. < 25 g/day had a 1.78 (95% CI: 1.00-3.16) higher risk of HF. Consumption of unprocessed meat was not associated with increased risk of HF incidence.
Findings from this prospective study of women indicate that processed red meat, but not unprocessed red meat, consumption is associated with an increased risk of HF incidence.
关于红肉消费与心力衰竭（HF）风险的流行病学研究有限。我们研究了长期未加工红肉和加工红肉消费与女性HF发病率之间的关联。
基于人群的前瞻性瑞典乳腺X线摄影队列包括34057名年龄在48 - 83岁之间、基线时（1997年）无HF或缺血性心脏病病史的女性。1997年使用自我管理的食物频率问卷（FFQ）以及1987 - 1990年实施的FFQ对肉类消费进行评估。使用Cox比例风险回归模型估计风险比（HR）及95%置信区间（CI）。
在平均13.2年的随访期间，2806名女性被诊断为HF。加工肉类消费（1997年FFQ）与HF发病率在统计学上呈显著正相关。与每天食用量小于25克的女性相比，每天食用量≥50克加工红肉的女性患HF的风险高1.23倍（95% CI：1.09 - 1.39，P趋势 = 0.003）。与每天食用量小于25克相比，长期高消费加工红肉（1987年至1997年平均）≥50克/天与HR为1.30相关（95% CI：1.05 - 1.60，P趋势 = 0.002）。在1987年和1997年都持续每天食用量≥50克与小于25克的女性相比，患HF的风险高1.78倍（95% CI：1.00 - 3.16）。未加工肉类消费与HF发病率增加无关。
这项针对女性的前瞻性研究结果表明，加工红肉而非未加工红肉的消费与HF发病率增加有关。
