Departments of Nutrition, Harvard TH Chan School of Public Health, Boston, MA.
Environmental Health, Harvard TH Chan School of Public Health, Boston, MA.
Am J Clin Nutr. 2018 Nov 1;108(5):1104-1112. doi: 10.1093/ajcn/nqy185.
Some dietary factors have been linked to outcomes of infertility treatment with assisted reproductive technology (ART), but the role of intake of meats and other protein-rich foods remains unclear.
The aim of this manuscript was to study the relation between preconception intake of meat and other protein-rich foods and outcomes of infertility treatment with ART.
A total of 351 women enrolled in a prospective cohort at the Massachusetts General Hospital Fertility Center and underwent 598 ART cycles for infertility treatment. Meat intake was assessed with a validated food-frequency questionnaire, and ART outcomes were abstracted from electronic medical records. We estimated the associations between intake of protein-rich foods (meats, eggs, beans, nuts, and soy) and the outcome of live birth per initiated cycle using generalized linear mixed models.
The average total meat intake was 1.2 servings/d, with most coming from poultry (35%), fish (25%), processed meat (22%), and red meat (17%). Fish intake was positively related to the proportion of cycles resulting in live birth. The multivariable-adjusted probabilities of live birth for women in increasing quartiles of fish intake were 34.2% (95% CI: 26.5%, 42.9%), 38.4% (95% CI: 30.3%, 47.3%), 44.7% (95% CI: 36.3%, 53.4%), and 47.7% (95% CI: 38.3%, 57.3%), respectively (P-trend = 0.04). In the estimated substitution analyses, the ORs of live birth associated with increasing fish intake by 2 servings/wk were 1.54 (95% CI: 1.14, 2.07) when fish replaced any other meat, 1.50 (95% CI: 1.13, 1.98) when fish replaced any other protein-rich food, and 1.64 (95% CI: 1.14, 2.35) when fish replaced processed meat.
Fish consumption is related to a higher probability of live birth following infertility treatment with ART. This trial was registered at clinicaltrials.gov as NCT00011713.
一些饮食因素与辅助生殖技术（ART）治疗不孕的结果有关，但摄入肉类和其他富含蛋白质的食物的作用仍不清楚。
本研究旨在探讨孕前摄入肉类和其他富含蛋白质的食物与 ART 治疗不孕的结果之间的关系。
共有 351 名在马萨诸塞州综合医院生育中心参加前瞻性队列研究的女性接受了 598 个用于治疗不孕的 ART 周期。通过验证后的食物频率问卷评估肉类摄入量，从电子病历中提取 ART 结果。我们使用广义线性混合模型估计了富含蛋白质的食物（肉类、鸡蛋、豆类、坚果和大豆）摄入量与每个启动周期活产率之间的关系。
平均总肉摄入量为 1.2 份/天，其中大部分来自家禽（35%）、鱼类（25%）、加工肉类（22%）和红色肉类（17%）。鱼类摄入量与活产率呈正相关。鱼类摄入量递增的四分位数女性活产率分别为 34.2%（95%CI：26.5%，42.9%）、38.4%（95%CI：30.3%，47.3%）、44.7%（95%CI：36.3%，53.4%）和 47.7%（95%CI：38.3%，57.3%）（P 趋势=0.04）。在估计的替代分析中，每周增加 2 份鱼类摄入量与活产率相关的 OR 分别为：当鱼类替代任何其他肉类时为 1.54（95%CI：1.14，2.07），当鱼类替代任何其他富含蛋白质的食物时为 1.50（95%CI：1.13，1.98），当鱼类替代加工肉类时为 1.64（95%CI：1.14，2.35）。
鱼类摄入与接受 ART 治疗不孕后的活产率较高有关。本试验在 clinicaltrials.gov 注册为 NCT00011713。
