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多功能纳米颗粒在癌症成像与治疗中的靶向策略

Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy.

作者信息

Yu Mi Kyung, Park Jinho, Jon Sangyong

机构信息

Cell Dynamics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, 261 Chemdangwagi-ro, Gwangju 500-712, Republic of Korea.

出版信息

Theranostics. 2012;2(1):3-44. doi: 10.7150/thno.3463. Epub 2012 Jan 1.

DOI:10.7150/thno.3463
PMID:22272217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3263514/
Abstract

Nanomaterials offer new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions including targeting, imaging, therapy, and etc have been intensively studied aiming to overcome limitations associated with conventional cancer diagnosis and therapy. Of various nanoparticles, magnetic iron oxide nanoparticles with superparamagnetic property have shown potential as multifunctional nanoparticles for clinical translation because they have been used asmagnetic resonance imaging (MRI) constrast agents in clinic and their features could be easily tailored by including targeting moieties, fluorescence dyes, or therapeutic agents. This review summarizes targeting strategies for construction of multifunctional nanoparticles including magnetic nanoparticles-based theranostic systems, and the various surface engineering strategies of nanoparticles for in vivo applications.

摘要

纳米材料为癌症诊断和治疗提供了新的机遇。具有靶向、成像、治疗等多种功能的多功能纳米粒子已得到深入研究，旨在克服传统癌症诊断和治疗的局限性。在各种纳米粒子中，具有超顺磁性的磁性氧化铁纳米粒子已显示出作为多功能纳米粒子用于临床转化的潜力，因为它们已在临床上用作磁共振成像（MRI）造影剂，并且通过包含靶向部分、荧光染料或治疗剂可以轻松调整其特性。本文综述了构建多功能纳米粒子（包括基于磁性纳米粒子的诊疗系统）的靶向策略，以及纳米粒子用于体内应用的各种表面工程策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/3075673bc3f9/thnov02p0003g23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/f5838919b1f8/thnov02p0003g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/751f8bf0dbdd/thnov02p0003g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/3ec52ee95b12/thnov02p0003g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/c266b4bc543f/thnov02p0003g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/04a59e49fadd/thnov02p0003g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/a6420c26b8df/thnov02p0003g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/c17063f7b658/thnov02p0003g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/55b95a3c83e8/thnov02p0003g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/2aa49075a241/thnov02p0003g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/292fea6f7cbc/thnov02p0003g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/eda6abebbd4f/thnov02p0003g16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/657f5de28301/thnov02p0003g17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/1a2b9b82acfe/thnov02p0003g18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/11fa92706847/thnov02p0003g19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/b9a07f33f8f9/thnov02p0003g20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/733ffed0b854/thnov02p0003g21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/21976ecc1d8b/thnov02p0003g22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/3075673bc3f9/thnov02p0003g23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/f5838919b1f8/thnov02p0003g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/751f8bf0dbdd/thnov02p0003g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/3ec52ee95b12/thnov02p0003g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/c266b4bc543f/thnov02p0003g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/04a59e49fadd/thnov02p0003g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/a6420c26b8df/thnov02p0003g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/c17063f7b658/thnov02p0003g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/55b95a3c83e8/thnov02p0003g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/2aa49075a241/thnov02p0003g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/292fea6f7cbc/thnov02p0003g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/eda6abebbd4f/thnov02p0003g16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/657f5de28301/thnov02p0003g17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/1a2b9b82acfe/thnov02p0003g18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/11fa92706847/thnov02p0003g19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/b9a07f33f8f9/thnov02p0003g20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/733ffed0b854/thnov02p0003g21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/21976ecc1d8b/thnov02p0003g22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20ae/3263514/3075673bc3f9/thnov02p0003g23.jpg

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