Riggins Rebecca B
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057 USA.
Receptors Clin Investig. 2014;1(5).
Estrogen-related receptors (ERRs) are orphan members of the nuclear receptor superfamily that are important regulators of mitochondrial metabolism with emerging roles in cancer. In the absence of an endogenous ligand, ERRs are reliant upon other regulatory mechanisms that include protein/protein interactions and post-translational modification, though the cellular and clinical significance of this latter mechanism is unclear. We recently published a study in which we establish estrogen-related receptor gamma (ERRγ) as a target for extracellular signal-regulated kinase (ERK), and show that regulation of ERRγ by ERK has important consequences for the function of this receptor in cellular models of estrogen receptor-positive (ER+) breast cancer. In this Research Highlight, we discuss the implications of these findings from a molecular and clinical perspective.
雌激素相关受体（ERRs）是核受体超家族的孤儿成员，是线粒体代谢的重要调节因子，在癌症中发挥着越来越重要的作用。在缺乏内源性配体的情况下，ERRs依赖于其他调节机制，包括蛋白质/蛋白质相互作用和翻译后修饰，尽管后一种机制的细胞和临床意义尚不清楚。我们最近发表了一项研究，其中我们将雌激素相关受体γ（ERRγ）确定为细胞外信号调节激酶（ERK）的靶点，并表明ERK对ERRγ的调节对雌激素受体阳性（ER+）乳腺癌细胞模型中该受体的功能具有重要影响。在本研究亮点中，我们从分子和临床角度讨论了这些发现的意义。
