Botros B A, Watts D M, Soliman A K, Salib A W, Moussa M I, Mursal H, Douglas C, Farah M
Virology Division, U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.
J Med Virol. 1989 Oct;29(2):79-81. doi: 10.1002/jmv.1890290202.
Epidemics of a malaria-like illness affected several thousand residents of the Dam Camp, a refugee camp near Hargeysa in Somalia, during 1985, 1986, and 1987. The disease was characterized by fever, chills, sweats, headache, back and joint pains for as long as 10 days in some patients. Blood smears from acutely ill patients were negative for malaria. Of 28 acute and 10 convalescent sera tested by the indirect fluorescent antibody (IFA) and by the hemagglutination inhibition (HI) tests, all were negative for antibody to Rift Valley fever, Crimean-Congo hemorrhagic fever, Sindbis, Chikungunya, yellow fever, and Zika viruses. However, antibody reactive to dengue 2 virus was detected by the IFA test in 39% (15/38), and 11 of 29 (38%) of the same sera were antibody positive by the HI test. Also, IgG antibody reactive to dengue 2 was demonstrated in 60% (17/28) of the same sera by the enzyme immunoassay (EIA), and 14% (4/28) were positive for IgM antibody. Of ten patients for which acute and convalescent sera were available, two developed four fold or greater rises in antibody titer evidencing infection. These data suggested that dengue virus may have been the cause of the epidemic among the Dam Camp refugees.
1985年、1986年和1987年期间，一种类似疟疾的疾病在索马里哈尔格萨附近的难民营达姆营感染了数千名居民。该病的特征为发热、寒战、出汗、头痛，部分患者的背痛和关节痛可持续长达10天。急性病患者的血涂片疟原虫检测呈阴性。通过间接荧光抗体（IFA）和血凝抑制（HI）试验检测的28份急性期血清和10份恢复期血清，均未检测到抗裂谷热、克里米亚-刚果出血热、辛德毕斯、基孔肯雅、黄热和寨卡病毒的抗体。然而，IFA试验在39%（15/38）的血清中检测到了抗登革2病毒的抗体，HI试验在29份相同血清中的11份（38%）中检测到抗体阳性。此外，酶免疫测定（EIA）在60%（17/28）的相同血清中检测到了抗登革2的IgG抗体，14%（4/28）的IgM抗体呈阳性。在有急性期和恢复期血清的10名患者中，有2名患者的抗体滴度升高了4倍或更高，表明发生了感染。这些数据表明，登革病毒可能是达姆营难民中疫情的病因。
