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金属纳米粒子:治疗癌症的诊断与治疗一体化纳米工具

Metal nanoparticles: a theranostic nanotool against cancer.

机构信息

Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.

Department of Wood Science, Mendel University in Brno, Brno, Czech Republic.

出版信息

Drug Discov Today. 2015 Sep;20(9):1143-51. doi: 10.1016/j.drudis.2015.05.009. Epub 2015 May 22.

Abstract

Cancer remains one of the most deadly diseases worldwide, but conventional anticancer therapies come with several drawbacks. Therefore, there is a need to develop new anticancer strategies. Theranostics is a strategy that combines treatment with diagnosis and monitoring. Metal nanoparticles are proposed as one of the most promising theranostic agents for the treatment of cancer. Thus, metals including iron, gold (Au), silver (Ag), zinc (Zn), and titanium, have potential as anticancer agents, either inherently or as a result of surface modifications. As a functional component of theranostic tools, metal nanoparticles have crucial dual roles as a diagnostic and active therapeutic agent for the treatment of cancer.

摘要

癌症仍然是全球最致命的疾病之一,但传统的抗癌疗法存在一些缺点。因此,需要开发新的抗癌策略。治疗学是一种将治疗与诊断和监测相结合的策略。金属纳米粒子被提议作为治疗癌症最有前途的治疗学试剂之一。因此,包括铁、金(Au)、银(Ag)、锌(Zn)和钛在内的金属具有作为抗癌剂的潜力,无论是固有地还是由于表面修饰。作为治疗学工具的功能组件,金属纳米粒子在癌症的诊断和主动治疗方面发挥着至关重要的双重作用。

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