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探索癌症的宝贵见解:利用双金属金/银纳米结构从基因到人体的传递

Golden insights for exploring cancer: delivery, from genes to the human body using bimetallic Au/Ag nanostructures.

作者信息

Khan Misbah Ullah, Aslam Humaira, Sohail Jehanzeb, Umar Ali, Ullah Aman, Ullah Hayat

机构信息

Centre for Nanosciences, University of Okara, Okara, 56130, Pakistan.

Department of Zoology, Faculty of Life Sciences, University of Okara, Okara, 56130, Pakistan.

出版信息

Discov Oncol. 2025 May 25;16(1):918. doi: 10.1007/s12672-025-02714-w.

Abstract

Sweeping contact with cancer continues to rise globally, which has led to advanced research on new treatment approaches; nanotechnology has become crucial to targeted cancer therapy. Within the intimate of nanomaterials, Au/Ag nanostructures have emerged as highly attractive because of their distinctive desirable characteristics and their prospective roles in diagnosis as well as cancer therapy. The nanostructures developed revealed remarkable biocompatibility, optically recursive alteration, and magnificently improved therapeutic effects of gold and silver in conjunction with each other. This review addresses the molecular and systemic aspects of Au/Ag nanostructures in cancer research, including the impact of nanostructures on the molecular genetic pathways and their use of systemic administration in the human organism. We explain some of the related mechanisms of action, such as photothermal therapy (PTT), and photodynamic therapy (PDT), as well as the drug delivery systems where they display potential benefits towards offering a more targeted treatment approach with fewer side effects. The latest development has shown that they have the prospect of real-time imaging and biomarker identification, and owing to this they are being viewed as a tool for individualized treatment. However, there are still some limitations: challenges of scaling up, biological safety, and bringing it to the clinic. It is therefore incumbent upon these managements to overcome these hurdles to optimize for their impact. As a result, the current findings are briefly reviewed, and the development directions are discussed to support the revolutionary role of Au/Ag nanostructures in cancer research and therapy.

摘要

全球范围内与癌症的广泛接触持续增加,这促使人们对新的治疗方法进行深入研究;纳米技术已成为靶向癌症治疗的关键。在纳米材料领域,金/银纳米结构因其独特的优良特性以及在癌症诊断和治疗中的潜在作用而备受关注。所开发的纳米结构显示出卓越的生物相容性、光学递归变化,以及金和银相互结合后显著提高的治疗效果。本文综述了金/银纳米结构在癌症研究中的分子和系统方面,包括纳米结构对分子遗传途径的影响及其在人体中的全身给药应用。我们解释了一些相关的作用机制,如光热疗法(PTT)和光动力疗法(PDT),以及它们在药物递送系统中显示出的潜在益处,即提供一种更具靶向性且副作用更少的治疗方法。最新进展表明,它们具有实时成像和生物标志物识别的前景,因此被视为个体化治疗的工具。然而,仍然存在一些局限性:扩大规模的挑战、生物安全性以及将其应用于临床的问题。因此,这些管理人员有责任克服这些障碍,以优化其影响。为此,本文简要回顾了当前的研究结果,并讨论了发展方向,以支持金/银纳米结构在癌症研究和治疗中的革命性作用。

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