Kuchur O A, Tsymbal S A, Shestovskaya M V, Serov N S, Dukhinova M S, Shtil A A
International Institute 'Solution Chemistry of Advanced Materials and Technologies', ITMO University, 197101 Saint-Petersburg, Russia.
International Institute 'Solution Chemistry of Advanced Materials and Technologies', ITMO University, 197101 Saint-Petersburg, Russia.
J Inorg Biochem. 2020 Aug;209:111117. doi: 10.1016/j.jinorgbio.2020.111117. Epub 2020 May 21.
Initially, metal derived nanoparticles have been used exclusively as contrasting agents in magnetic resonance imaging. Today, green routes of chemical synthesis together with numerous modifications of the core and surface gave rise to a plethora of biomedical applications of metal derived nanoparticles including tumor imaging, diagnostics, and therapy. These materials are an emerging class of tools for tumor theranostics. Nevertheless, the spectrum of clinically approved metal nanoparticles remains narrow, as the safety, specificity and efficiency still have to be improved. In this review we summarize the major directions for development and biomedical applications of metal based nanoparticles and analyze their effects on tumor cells and microenvironment. We discuss the advantages and possible limitations of metal nanoparticle-based tumor theranostics, as well as the potential strategies to improve the in vivo performance of these unique materials.
最初，金属衍生的纳米颗粒仅被用作磁共振成像中的造影剂。如今，化学合成的绿色途径以及对核心和表面的大量修饰，催生了金属衍生纳米颗粒在生物医学领域的众多应用，包括肿瘤成像、诊断和治疗。这些材料是一类新兴的肿瘤诊疗工具。然而，临床批准的金属纳米颗粒的范围仍然狭窄，因为其安全性、特异性和效率仍有待提高。在本综述中，我们总结了金属基纳米颗粒的主要发展方向和生物医学应用，并分析了它们对肿瘤细胞和微环境的影响。我们讨论了基于金属纳米颗粒的肿瘤诊疗的优势和可能的局限性，以及提高这些独特材料体内性能的潜在策略。
