Goldberg Robert J, Saczynski Jane S, McManus David D, Waring Molly E, McManus Richard, Allison Jeroan, Parish David C, Lessard Darleen, Person Sharina, Gore Joel M, Kiefe Catarina I
Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.
Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester; Department of Medicine, University of Massachusetts Medical School, Worcester.
Am J Med. 2015 Oct;128(10):1087-93. doi: 10.1016/j.amjmed.2015.05.002. Epub 2015 May 23.
Limited contemporary data compare the clinical and psychosocial characteristics and acute management of patients hospitalized with an initial vs a recurrent episode of acute coronary disease. We describe these factors in a cohort of patients recruited from 6 hospitals in Massachusetts and Georgia after an acute coronary syndrome.
We performed structured baseline in-person interviews and medical record abstractions for 2174 eligible and consenting patients surviving hospitalization for an acute coronary syndrome between April 2011 and May 2013.
The average patient age was 61 years, 64% were men, and 47% had a high school education or less; 29% had a low general quality of life, and 1 in 5 were cognitively impaired. Patients with a recurrent coronary episode had a greater burden of previously diagnosed comorbidities. Overall, psychosocial burden was high, and more so in those with a recurrent vs those with an initial episode. Patients with an initial coronary episode were as likely to have been treated with all 4 effective cardiac medications (51.6%) as patients with a recurrent episode (52.3%), but were significantly more likely to have undergone cardiac catheterization (97.9% vs 92.9%) and a percutaneous coronary intervention (73.7% vs 60.9%) (P < .001) during their index hospitalization.
Patients with a first episode of acute coronary artery disease have a more favorable psychosocial profile, less comorbidity, and receive more invasive procedures but similar medical management, than patients with previously diagnosed coronary disease. Implications of the high psychosocial burden on various patient-related outcomes require investigation.
目前关于急性冠状动脉疾病初发与复发患者住院期间临床及社会心理特征和急性处理的比较数据有限。我们描述了从马萨诸塞州和佐治亚州6家医院招募的急性冠状动脉综合征患者队列中的这些因素。
我们对2011年4月至2013年5月期间因急性冠状动脉综合征住院存活且符合条件并同意参与的2174例患者进行了结构化的基线当面访谈和病历摘要分析。
患者平均年龄为61岁,64%为男性,47%接受过高中及以下教育;29%总体生活质量较低,五分之一存在认知障碍。复发性冠状动脉事件患者先前诊断的合并症负担更重。总体而言,社会心理负担较重,复发性事件患者比初发性事件患者更重。初发性冠状动脉事件患者接受4种有效心脏药物治疗的比例(51.6%)与复发性事件患者(52.3%)相似,但在其索引住院期间接受心脏导管插入术(97.9%对92.9%)和经皮冠状动脉介入治疗(73.7%对60.9%)的可能性显著更高(P <.001)。
与先前诊断为冠状动脉疾病的患者相比,首次发生急性冠状动脉疾病的患者具有更有利的社会心理状况,合并症更少,接受的侵入性操作更多,但药物治疗相似。社会心理负担对各种患者相关结局的影响需要进一步研究。