Moss Heather E
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL, USA,
Curr Neurol Neurosci Rep. 2015 Jul;15(7):40. doi: 10.1007/s11910-015-0561-1.
The retinal circulation is a potential marker of cerebral vascular disease because it shares origin and drainage with the intracranial circulation and because it can be directly visualized using ophthalmoscopy. Cross-sectional and cohort studies have demonstrated associations between chronic retinal and cerebral vascular disease, acute retinal and cerebral vascular disease, and chronic retinal vascular disease and acute cerebral vascular disease. In particular, certain qualitative features of retinopathy, retinal artery occlusion, and increased retinal vein caliber are associated with concurrent and future cerebrovascular events. These associations persist after accounting for confounding variables known to be disease-causing in both circulations, which supports the potential use of retinal vasculature findings to stratify individuals with regards to cerebral vascular disease risk.
视网膜循环是脑血管疾病的一个潜在标志物，因为它与颅内循环有着共同的起源和引流途径，并且可以通过检眼镜直接观察到。横断面研究和队列研究已经证明了慢性视网膜和脑血管疾病之间、急性视网膜和脑血管疾病之间以及慢性视网膜血管疾病和急性脑血管疾病之间的关联。特别是，视网膜病变、视网膜动脉阻塞和视网膜静脉管径增宽的某些定性特征与同时发生的和未来的脑血管事件相关。在考虑了已知在两个循环中都可致病的混杂变量后，这些关联依然存在，这支持了利用视网膜血管系统的发现对个体的脑血管疾病风险进行分层的潜在用途。
