评估不明病因绒毛炎时观察者的可靠性。
Observer reliability in assessing villitis of unknown aetiology.
作者信息
Khong T Y, Staples A, Moore L, Byard R W
机构信息
Department of Pathology, Queen Victoria Hospital, Australia.
出版信息
J Clin Pathol. 1993 Mar;46(3):208-10. doi: 10.1136/jcp.46.3.208.
AIMS
To evaluate observer variation in diagnosis of villitis of unknown aetiology.
METHODS
Fifty haematoxylin and eosin stained sections were circulated to three pathologists who were asked to assess if villitis was present. These slides, with an additional 20, were recirculated and reassessed by the same pathologists.
RESULTS
Intra-observer agreement was 84.7% (range 74--92%) and interobserver agreement was 81%. A conjoint review by the three pathologists revealed that sources of differences included the overlooking of isolated single or small numbers of affected villi, the difficulty in assessing stromal cellularity close to infarcted parenchyma, and apparent stromal hypercellularity in immature villi.
CONCLUSIONS
Experienced pathologists can show a significant interobserver variation in assessing villitis of unknown aetiology. Future studies on villitis of unknown aetiology should address the problem of observer reproducibility of diagnosis.
目的
评估病因不明的绒毛炎诊断中观察者间的差异。
方法
向三位病理学家分发50张苏木精和伊红染色切片，要求他们评估是否存在绒毛炎。这些切片以及另外20张切片再次分发给相同的病理学家进行重新评估。
结果
观察者内一致性为84.7%（范围74 - 92%），观察者间一致性为81%。三位病理学家联合审查发现，差异来源包括孤立的单个或少量受影响绒毛被忽视、靠近梗死实质处的间质细胞密度评估困难以及未成熟绒毛中明显的间质细胞增多。
结论
经验丰富的病理学家在评估病因不明的绒毛炎时，观察者间差异显著。未来关于病因不明的绒毛炎的研究应解决诊断的观察者可重复性问题。
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