由膦配位钴催化剂促进的烯烃异构化-硼氢化反应
Alkene isomerization-hydroboration promoted by phosphine-ligated cobalt catalysts.
作者信息
Scheuermann Margaret L, Johnson Elizabeth J, Chirik Paul J
机构信息
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
出版信息
Org Lett. 2015 Jun 5;17(11):2716-9. doi: 10.1021/acs.orglett.5b01135. Epub 2015 May 26.
Generated in situ from air-stable cobalt precursors or readily synthesized using NaHBEt3, (PPh3)3CoH(N2) was found to be an effective catalyst for the hydroboration of alkenes. Unlike previous base-metal catalysts for alkene isomerization-hydroboration which favor the incorporation of boron at terminal positions, (PPh3)3CoH(N2) promotes boron incorporation adjacent to π-systems even in substrates where the alkene is at a remote position, enabling a unique route to 1,1-diboron compounds from α,ω-dienes.
（三苯基膦）₃CoH（N₂）可由空气稳定的钴前体原位生成，或使用NaHBEt₃轻松合成，它被发现是烯烃硼氢化反应的有效催化剂。与之前用于烯烃异构化-硼氢化反应的贱金属催化剂不同，后者倾向于在末端位置引入硼，而（三苯基膦）₃CoH（N₂）即使在烯烃处于较远位置的底物中，也能促进硼在π体系附近的引入，从而为从α,ω-二烯合成1,1-二硼化合物提供了一条独特的途径。
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