Kremer Stephane, Renard Felix, Achard Sophie, Lana-Peixoto Marco A, Palace Jacqueline, Asgari Nasrin, Klawiter Eric C, Tenembaum Silvia N, Banwell Brenda, Greenberg Benjamin M, Bennett Jeffrey L, Levy Michael, Villoslada Pablo, Saiz Albert, Fujihara Kazuo, Chan Koon Ho, Schippling Sven, Paul Friedemann, Kim Ho Jin, de Seze Jerome, Wuerfel Jens T, Cabre Philippe, Marignier Romain, Tedder Thomas, van Pelt Danielle, Broadley Simon, Chitnis Tanuja, Wingerchuk Dean, Pandit Lekha, Leite Maria Isabel, Apiwattanakul Metha, Kleiter Ingo, Prayoonwiwat Naraporn, Han May, Hellwig Kerstin, van Herle Katja, John Gareth, Hooper D Craig, Nakashima Ichiro, Sato Douglas, Yeaman Michael R, Waubant Emmanuelle, Zamvil Scott, Stüve Olaf, Aktas Orhan, Smith Terry J, Jacob Anu, O'Connor Kevin
ICube (UMR 7357, UdS, Centre National de la Recherche Scientifique), Fédération de médecine translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France2Department of Radiology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Centre National de la Recherche Scientifique, Grenoble Image Parole Signal Automatique, Grenoble, France.
JAMA Neurol. 2015 Jul;72(7):815-22. doi: 10.1001/jamaneurol.2015.0248.
Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.
在视神经脊髓炎谱系障碍（NMO）患者的常规磁共振成像（MRI）扫描中经常观察到脑实质病变，但尚未确定将它们与其他疾病引起的病变明确区分开来的特定形态学和时间模式。这篇文献综述总结了有关NMO谱系障碍患者的先进定量成像测量的文献，包括质子磁共振波谱、扩散张量成像、磁化传递成像、定量磁共振容积测量和超高场强MRI。它旨在考虑该领域不同专家用于NMO患者的先进MRI技术。尽管诸如质子磁共振波谱或磁化传递成像等定量测量尚未能重复性地揭示弥漫性脑损伤，但来自扩散加权成像和脑组织容积测量的初步数据表明白质降解比灰质更严重。这些发现可通过超高场MRI得到证实。使用非常规MRI技术可能会加深我们对NMO谱系障碍致病过程的理解，并可能帮助我们识别与该疾病特定表型表现相对应的独特影像学特征。
