Adedeji Tewogbade Adeoye, Adedeji Nife O, Adebisi Simeon A, Idowu Ademola A, Fawale Michael B, Jimoh Kayode A
Department of Chemical Pathology, Obafemi Awolowo University, Ile-Ife, Nigeria
State Specialist Hospital, Ile-Ife, Nigeria.
J Int Assoc Provid AIDS Care. 2015 Sep-Oct;14(5):434-40. doi: 10.1177/2325957415587570. Epub 2015 May 26.
Chronic renal failure and HIV/AIDS are both prevalent in Nigeria. We performed a cross-sectional analysis of renal function in newly diagnosed, treatment-naive HIV-infected patients before initiating highly active antiretroviral therapy.
Treatment-inexperienced individuals were recruited. Patients with diabetes mellitus and hypertension were excluded. Plasma creatinine level was used to measure the estimated glomerular filtration rate ([eGFR] by Modification of Diet in Renal Disease equation). Predictors of creatinine and eGFR were determined by univariate and multivariate analyses.
We evaluated 183 patients. In all, 44 (24%) patients had a GFR <60 mL/min/1.73 m(2), implying moderate chronic kidney disease (CKD). Considering the eGFR, 22 (12%) patients had stage 1, 117 (63.9%) stage 2, 13 (7.1%) stage 3, 27 (14.8%) stage 4, and 4 (2.2%) stage 5 CKD. Creatinine inversely correlated with CD4 (r = -.228, P = .025). CD4 predicts creatinine (odds ratio 1.6, 95% confidence interval 1.0-1.8, P = .003).
In ART-naive patients, CKD is common, and low eGFR was associated with lower CD4 counts.
慢性肾衰竭和艾滋病毒/艾滋病在尼日利亚都很普遍。我们对新诊断的、未接受过治疗的艾滋病毒感染患者在开始高效抗逆转录病毒治疗前的肾功能进行了横断面分析。
招募未接受过治疗的个体。排除患有糖尿病和高血压的患者。使用血浆肌酐水平来测量估计肾小球滤过率（根据肾脏疾病饮食改良方程计算的[eGFR]）。通过单变量和多变量分析确定肌酐和eGFR的预测因素。
我们评估了183名患者。总共有44名（24%）患者的肾小球滤过率<60 mL/分钟/1.73平方米，这意味着中度慢性肾脏病（CKD）。根据eGFR，22名（12%）患者处于1期，117名（63.9%）处于2期，13名（7.1%）处于3期，27名（14.8%）处于4期，4名（2.2%）处于5期CKD。肌酐与CD4呈负相关（r = -.228，P = .025）。CD4可预测肌酐（比值比1.6，95%置信区间1.0 - 1.8，P = .003）。
在未接受抗逆转录病毒治疗的患者中，CKD很常见，且低eGFR与较低的CD4计数相关。
