无配体铜催化的烷基、芳基和炔基锌试剂与杂芳基碘化物的 Negishi 偶联反应。
Ligand-Free Copper-Catalyzed Negishi Coupling of Alkyl-, Aryl-, and Alkynylzinc Reagents with Heteroaryl Iodides.
机构信息
Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA).
出版信息
Angew Chem Int Ed Engl. 2015 Jul 6;54(28):8236-40. doi: 10.1002/anie.201502379. Epub 2015 May 28.
PMID:26016822
Abstract
Reported herein is an unprecedented ligand-free copper-catalyzed cross-coupling of alkyl-, aryl-, and alkynylzinc reagents with heteroaryl iodides. The reaction proceeds at room temperature for the coupling of primary, secondary, and tertiary alkylzinc reagents with heteroaryl iodides without rearrangement. An elevated temperature (100 °C) is required for aryl-heteroaryl and alkynyl-heteroaryl couplings.
摘要
本文报道了首例无配体的铜催化烷基、芳基和炔基锌试剂与杂芳基碘化物的交叉偶联反应。该反应在室温下进行，伯、仲和叔烷基锌试剂与杂芳基碘化物偶联时无重排。芳基-杂芳基和炔基-杂芳基偶联需要升高温度（100°C）。
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