Department of Chemistry, York University 4700 Keele Street, Toronto, ON, M3J1P3, Canada.
Chem Commun (Camb). 2011 May 14;47(18):5181-3. doi: 10.1039/c0cc04835f. Epub 2011 Feb 1.
Pd-PEPPSI-IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, β-hydride elimination/migratory insertion of the organometallic leading to the production of isomeric coupling products has been significantly reduced using the highly-hindered Ipent ligand.
Pd-PEPPSI-IPent 已被证明是 Negishi 交叉偶联反应的一种极好的催化剂，可用于各种芳基/杂芳基卤化物与二级烷基锌试剂的偶联反应。重要的是，使用高度位阻的 Ipent 配体，大大减少了导致异构偶联产物生成的有机金属β-氢消除/迁移插入。
