Heo Hye-Ryeon, Chen Li, An Borim, Kim Kye-Seong, Ji Junfeng, Hong Seok-Ho
Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
Center of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Int J Stem Cells. 2015 May;8(1):18-23. doi: 10.15283/ijsc.2015.8.1.18.
Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.
自我更新和分化是干细胞的标志，受多种内在和外在因素的控制。越来越多的证据表明，雌激素（E2）作为主要的女性性激素，参与调节成体干细胞和多能干细胞的增殖及谱系定向，以及调节干细胞微环境。因此，详细了解E2在干细胞行为中的作用可能有助于提高其治疗潜力。最近，有报道称E2在孕期可促进造血干细胞和祖细胞的细胞周期活性，并诱导它们分化为巨核-红系祖细胞。这项研究为一种此前未被探索的控制干细胞行为的内分泌机制铺平了道路。在这篇综述中，我们将重点关注关于E2对包括其微环境在内的造血系统的调节作用的科学发现。
