造血干细胞及其微环境的激素调节：聚焦雌激素
Hormonal regulation of hematopoietic stem cells and their niche: a focus on estrogen.
作者信息
Heo Hye-Ryeon, Chen Li, An Borim, Kim Kye-Seong, Ji Junfeng, Hong Seok-Ho
机构信息
Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
Center of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
出版信息
Int J Stem Cells. 2015 May;8(1):18-23. doi: 10.15283/ijsc.2015.8.1.18.
Abstract
Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.
摘要
自我更新和分化是干细胞的标志，受多种内在和外在因素的控制。越来越多的证据表明，雌激素（E2）作为主要的女性性激素，参与调节成体干细胞和多能干细胞的增殖及谱系定向，以及调节干细胞微环境。因此，详细了解E2在干细胞行为中的作用可能有助于提高其治疗潜力。最近，有报道称E2在孕期可促进造血干细胞和祖细胞的细胞周期活性，并诱导它们分化为巨核-红系祖细胞。这项研究为一种此前未被探索的控制干细胞行为的内分泌机制铺平了道路。在这篇综述中，我们将重点关注关于E2对包括其微环境在内的造血系统的调节作用的科学发现。
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本文引用的文献
1
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Biochimie. 2015 Mar;110:36-44. doi: 10.1016/j.biochi.2015.01.001. Epub 2015 Jan 7.
2
Activation of β-catenin stimulated by mechanical strain and estrogen requires estrogen receptor in mesenchymal stem cells (MSCs).机械应变和雌激素刺激的β-连环蛋白激活需要间充质干细胞（MSC）中的雌激素受体。
Eur Rev Med Pharmacol Sci. 2014;18(21):3149-55.
3
Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.雌激素信号选择性地诱导造血祖细胞和髓系肿瘤细胞凋亡，而不损害稳态造血。
Cell Stem Cell. 2014 Dec 4;15(6):791-804. doi: 10.1016/j.stem.2014.11.002.
4
The many faces of estrogen signaling.雌激素信号传导的多面性。
Biochem Med (Zagreb). 2014 Oct 15;24(3):329-42. doi: 10.11613/BM.2014.035. eCollection 2014.
5
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.干细胞疗法。利用分化的多能干细胞作为替代疗法来治疗疾病。
Science. 2014 Aug 22;345(6199):1247391. doi: 10.1126/science.1247391.
6
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7
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8
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Mol Cell Biochem. 2014 Jul;392(1-2):85-93. doi: 10.1007/s11010-014-2021-7. Epub 2014 Apr 22.
9
Role of the sex hormone estrogen in the prevention of lipid disorder.性激素雌激素在预防脂质紊乱中的作用。
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10
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